2.2 Platelet and Vascular Disorders

Question 1

Thrombotic thrombocytopenic purpura (TTP) is characterized by:
A. Prolonged PT
B. Increased PLT aggregation
C. Thrombocytosis
D. Prolonged APTT

Question 2

Thrombocytopenia may be associated with:
A. Splenectomy
B. Hypersplenism
C. Acute blood loss
D. Increased proliferation of pluripotent stem cells

Question 3

Aspirin prevents PLT aggregation by inhibiting the action of which enzyme?
A. Phospholipase
B. Cyclo-oxygenase
C. Thromboxane A2 (TXA2) synthetase
D. Prostacyclin synthetase

Question 4

Normal PLT adhesion depends on:
A. Fibrinogen
B. Glycoprotein Ib
C. Glycoprotein IIb-IIIa complex
D. Calcium

Question 5

Which of the following test results is normal in a patient with classic von Willebrand disease?
A. PLT aggregation
B. APTT
C. PLT count
D. Factor VIII:C and von Willebrand factor (VWF) levels

Question 6

Bernard-Soulier syndrome is associated with:
A. Decreased factor IX
B. Decreased factor VIII
C. Thrombocytopenia and giant PLTs
D. Abnormal PLT function test results