2.1.6 - Cell Division Flashcards
The Cell Cycle
The cell cycle is a sequence of events that takes place in a cell, resulting in division of the nucleus and the formation of two genetically identical daughter cells
Stages of cell cycle
Interphase : - G1 - S - G2 Mitotic phase - Mitosis - Cytokinesis
Interphase
- DNA replicated and checked for errors
- Protein synthesis
- Organelles grow and divide e.g. Mitochondria
- Normal metabolic processes occur e.g. Respiration
G1
- First growth phase
- Protein synthesis
- Organelles are synthesised
- Cell increases in size
S
- Synthesis phase
- DNA replicated
G2
- Second growth phase
- Energy stores are increased
- DNA checked for errors
G0
- G0 is when a cell leaves the cell cycle
Reasons for going to G0 - Differentiation - To become specialised
- Damaged DNA - It can no longer replicate (senescent)
- Age - The older you are the more senescent cells you have (linked with cancer and arthritis)
G1 checkpoint
- Cell size
- Nutrients
- Growth factors
- DNA damage
Metaphase checkpoint
- Chromosomes aligned
- Chromosomes attached to spindles
G2 checkpoint
- Cell size
- DNA replication
- DNA damage
Checkpoints
If the conditions are not satisfied in each checkpoint the cell enters G0
Cancer
- Caused by a mutation of genes that regulate the cell cycle
- Uncontrolled cell growth
- Forms a tumour
Stages of mitosis
- Prophase
- Metaphase
- Anaphase
- Telophase
Prophase
- Chromosomes condense and coil, so they shorten and thicken
- Chromosomes become visible
- Nuclear envelope and nucleolus disappear
- Centrioles move to opposite poles of the cell
Early prophase
- Chromosomes become visible
Late prophase
- Nuclear envelope and nucleolus disappear
- Centrioles migrate
Metaphase
- Chromosomes align at equator/ metaphase plate
- Attach to spindle by centromere
Anaphase
- Spindle fibres contract and shorten
- Chromatids separate and move to opposite poles
Telophase
- Nuclear envelope and nucleolus reform
- Chromosomes uncoil and become long and thin
Cytokinesis (Animal cells)
Cleavage furrow forms in the middle of the cell. The cell surface membrane is pulled inwards by the cytoplasm until it’s close enough to fuse around the middle, forming two cells.
Cytokinesis (Plant cells)
- Cell wall prevents cleavage
- Vesicles from the Golgi apparatus line up along the metaphase plate. Vesicles fuse with each other and the cell surface membrane dividing the cell into two.
Importance of mitosis
- Growth and repair
- Replace cells
- Asexual reproduction
- Maintain chromosome number in all cells
Homologous chromosomes
Matching pair of chromosomes, one inherited from each parent
Allele
Different versions of the same gene
Locus
The position of a gene on a chromosome