2130 Flashcards

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1
Q

Albuterol

Brand name

A

Brand name: proventil/ ventolin

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2
Q

Albuterol

Drug class

A

Drug class: sympathomimetic

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3
Q

Albuterol

Indications

A

Indications: treatment of bronchospasm in patients with reversible obstructive airway disease (COPD, asthma) prevention of exercise-induced bronchospasm.

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4
Q

Albuterol

Mechanism of action

A

Mechanism of action: selective beta-2 agonist that stimulates adrenergic receptors of the sympathomimetic nervous system. Results in smooth-muscle relaxation in the bronchial tree and peripheral vasculature. More selective for beta-2 than Albuterol

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5
Q

Albuterol

Contraindications

A

Contraindications: hypersensitivity, tachycardia, dysrhythmias, especially those caused by digitalis. Synergistic with other sympathomimetic

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6
Q

Albuterol

Adverse effects

A

Adverse effects: headaches, fatigue, lightheadedness, irritability, restlessness, aggressive behavior, pulmonary edema, hoarseness, nasal congestion, increased sputum, hypertension, tachycardia, dysrhythmias, chest pain, palpitations, N/V, dry mouth, epigastric pain, and tremors.

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7
Q

Albuterol

Precautions

A

Precautions: TCA’S may potentiate vasculature effects, beta blockers will antagonize effects may cause hypokalemia

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8
Q

Albuterol

Dose & administration

A

Dose & administration: adult 2.5mg dilute in 3ml NS nebulized over 10-15 minutes. Pediatric <20kg - 1.25mg/ dose via hand held nebulizer or mask over 20 minutes. Pediatrics >20kg - 2.5mg/ dose via hand held nebulizer or mask over 20 minutes

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9
Q

Etomidate

Brand name

A

Brand name: amidate

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10
Q

Etomidate

Drug class

A

Drug class: non-barbiturate hypnotic anesthesia induction agent.

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11
Q

Etomidate

Indications

A

Indications: premedication for tracheal intubation (RSI/SAI) or cardioversion

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12
Q

Etomidate

Mechanism of action

A

Mechanism of action: short- acting hypnotic that acts at the level of the reticular activating system within the brain.

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13
Q

Etomidate

Contraindications

A

Contraindications: hypersensitivity, labor & delivery

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14
Q

Etomidate

Adverse effects

A

Adverse effects: hypoventilation, hyperventilation, dysrhythmias, hypotension, hypertension, N/V, involuntary muscle movement, pain at injection site.

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15
Q

Etomidate

Precautions

A

Precautions: may be enhanced when given with other CNS depressants.

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16
Q

Etomidate

Dose & administration

A

Dose & administration: adult 0.2 to 0.6mg/kg iv over 30-60 seconds. Pediatrics 0.2 to 0.4mg/kg iv over 30-60 seconds

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17
Q

Lpratropium

Brand name

A

Brand name: atrovent

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18
Q

Ipratropium

Drug class

A

Drug class: anticholinergic

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19
Q

Ipratropium

Indications

A

Indications: persistent bronchospasm (asthma), COPD exacerbation.

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20
Q

Ipratropium

Mechanism of action

A

Mechanism of action: inhibits interaction of acetylcholine at receptor sites of bronchial smooth muscle ( in the lungs), resulting in decreased contractility of the bronchial smooth muscle and decrease in mucous production

21
Q

Ipratropium

Contraindications

A

Contraindications: hypersensitivity to ipratropium, atropine, alkaloids, peanuts. Note new manufacturing has eliminated the contraindications pertaining to peanuts and soy allergy

22
Q

Ipratropium

Adverse effects

A

Adverse effects: headache, dizziness, nervousness, fatigue, tremor, blurred vision, cough, dyspnea, worsening COPD symptoms, tachycardia, palpitations, flushing, MI, dry mouth, N/V, GI distress.

23
Q

Ipratropium

Precautions

A

Precautions: no drug interactions reported

24
Q

Ipratropium

Drug & administration

A

Drug & administration: adult 250 to 500 mcg (.25 to .5mg) inhalation with nebulizer every 20 minutes up to 3 times. Pediatrics same as adult.

25
Q

Levalbuterol

Brand name

A

Brand name: xopenex

26
Q

Levalbuterol

Drug class

A

Drug class: sympathomimetic, bronchodilator

27
Q

Levalbuterol

Indications

A

Indications: treatment of acute bronchospasm in patients with reversible obstructive airway disease (COPD, asthma). Bronchospasm prophylaxis (prevention/treatment) in asthma patients.

28
Q

Levalbuterol

Mechanism of action

A

Mechanism of action: stimulates beta-2 receptors resulting in smooth muscle relaxation of the bronchial tree and peripheral vasculature. More selective for beta-2 than albuterol.

29
Q

Levalbuterol

Contraindications

A

Contraindications: hypersensitivity, angioedema, tachydysrhythmias, severe cardiac disease.

30
Q

Levalbuterol

Adverse effects

A

Adverse effects: headache, anxiety, dizziness, restlessness, hallucinations, throat irritation, tachycardia, hypotension, hypertension, dysrhythmias, angina, N/V, dyspepsia, tremors, hypokalemia, hyperglycemia.

31
Q

Levalbuterol

Precautions

A

Precautions: increases action of bronchodilators, MAOI’S, TCA’s and other adrenergics. May cause a prolonged QT interval with sotalol or phenothiazine’s

32
Q

Levalbuterol

Dose & administration

A

Dose & administration: adult 1.25mg to 2.5mg in 3ml normal saline administered by nebulizer every 20 minutes to a maximum of 3 doses. Pediatrics 0.075mg/kg (minimum of 1.25mg) administered by nebulizer every 20 minutes to a maximum of 3 doses.

33
Q

Succinylcholine

Brand name

A

Brand name: anectine

34
Q

Succinylcholine

Drug class

A

Drug class: neuromuscular blocker, depolarizing; skeletal muscle relaxant

35
Q

Succinylcholine

Indications

A

Indications: RSI

36
Q

Succinylcholine

Mechanism of action

A

Mechanism of action: ultra short acting depolarizing skeletal muscle relaxant that mimics acetylcholine as it binds with the cholinergic receptors on the motor end plate, producing a phase 1 blocker as manifested by fasciculations.

37
Q

Succinylcholine

Contraindications

A

Contraindications: acute narrow-angle glaucoma, penetrating eye injuries, malignant hyperthermia. Acute injury after multisystem trauma, major burns, or extensive muscle injury. Inability to control airway or support ventilation with oxygen and positive pressure.

38
Q

Succinylcholine

Adverse effects

A

Adverse effects: bradydysrhythmia, tachydysrhythmia, dysrhythmia, cardiac arrest, salivation, prolonged muscle rigidity, rhabdomyolysis, malignant hyperthermia, increased intraocular pressure, hyperkalemia (trauma patients)

39
Q

Succinylcholine

Precautions

A

Precautions: oxytocin, beta blockers and organophosphates may potentiate effects, diazepam can reduce duration of action

40
Q

Succinylcholine

Dose & administration

A

Dose & administration: adult 1 to 1.5mg/kg rapid iv. Repeat once if needed. Pediatrics same as adult. Onset of 1 minute, peak 1 to 3 minutes, duration 5 to 10 minutes.

41
Q

Lidocaine

Brand name

A

Brand name: xylocaine

42
Q

Lidocaine

Drug class

A

Drug class: antidysrhythmic (sodium channel blocker)

43
Q

Lidocaine

Indications

A

Indications: alternative to amiodarone in cardiac arrest from ventricular tachycardia, ventricular fibrillation, stable wide complex tachycardia (poly- or monomorphic) with normal baseline QT interval, stable monomorphic VT with preserved ventricular function.

44
Q

Lidocaine

Mechanism of action

A

Mechanism of action: decreases automaticity by slowing the rate of spontaneous phase 4 depolarization: blocks Na+ channels in cardiac myocyte, slows depolarization, suppresses automaticity, resulting in stabilizing ectopic foci by increasing the threshold needed for depolarization.

45
Q

Lidocaine

Contraindications

A

Contraindications: hypersensitivity, second or third AV heart block in the absence of an artificial pacemaker, stokes Adam’s syndrome, wide complex ventricular escape beats with bradycardia.

46
Q

Lidocaine

Adverse effects

A

Adverse effects: anxiety, drowsiness, confusion, seizures, slurred speech, respiratory arrest, hypotension, bradycardia, dysrhythmias, cardiac arrest, AV block, N/V

47
Q

Lidocaine

Precautions

A

Precautions: caution in wolf Parkinson white syndrome cardiac depression seen with phenytoin metabolic clearance reduced with liver disease or use of beta blockers

48
Q

Lidocaine

Dose & administration

A

Dose & administration: adult v-tach/V-fib- 1.0 to 1.5mg/kg iv/io may be repeated in 5 to 10 minutes; dose - 0.5 to 0.75mg/kg iv/io maximum dose of 3mg/kg. Stable v-tach 0.5 to 0.75mg/kg iv/io. May repeat does in 5 to 10 minutes with maximum dose of 3mg/kg. Pediatrics 1mg/kg iv/io push with maximum dose of 100mg.