2.13 - Pharmacology of Psoriasis

Question 1

Is there a cure for psoriasis

Answer 1

No cure

Question 2

Vit D3 Agents (2)

Answer 2

Calcitriol and Calcipotriene

Question 3

MOA of Calcitriol and Calcipotrien

Answer 3

Vit D3 agents therefore important for regulation of Ca in body (can tell via name too)
- May inhibit production from cytokines from skin-infiltrating T-cells

Question 4

Retinoid Agents (2)

Answer 4

Acitretin and Tazarotene

Question 5

What are the 4 overall agents used for psoriasis

Answer 5

Vit D3 Agents, Retinoid Agents, Immunosuppressant agents, and Tumor Necrosis Factor Inhibitors.

Question 6

Pregnancy contraindication

Answer 6

Acitretin and Tazarotene (Retinoid Agents)

- Note, Immunosuppressant agents are also not recommended but not contraindicated

Question 7

MOA of Retinoid Agents

Answer 7

Binds to RAR and RXR and modulates the proliferation of keratinocytes.
- NOTE Tazarotene is a prodrug and therefore it’s the metabolites are what does the effect.

Question 8

Immunosuppressant Agents (2)

Answer 8

Tacrolimus and Pimecrolimus

Question 9

Therapeutic Use of Tacrolimus and Pimecrolimus

Answer 9

Plaque and inverse psoriasis on the FACE AND GENITALS (sensitive areas)

Question 10

Tumor Necrosis Factor Inhibitors (2)

Answer 10

Etanercept and Infliximab

Question 11

MOA of Etanercept (subcutaneous)

Answer 11

Bind TNF-alpha and beta => prevents TNF receptor interaction

Question 12

MOA of Infliximab (IV)

Answer 12

binds only to TNF-alpha => prevents TNF receptor interaction

Question 13

Contraindication for Etanercept

Answer 13

Sepsis

Question 14

Contraindication of Infliximab

Answer 14

Moderate to Severe heart failure

Question 15

Black box warning for Tumor Necrosis Factor Inhibitors

Answer 15

Serious infections and malignancy