21 st century Pharm/Ethics/Legal Flashcards
Define Reombinant Human Proteins.
Proteins made from recombinant DNA tech to replicate human proteins.
The production of insulin to manage diabetes Mellitus is an example of what?
Recombinant Human Proteins
Why are proteins not administered orally?
-Unstable to gastric acid
-Large molecular weight not absored well orally.
-Best administered parenterally.
What are monoclonal antibodies?
Manmade antibodies that are being explored to varies disease treatments.
What are the four monoclonoal antibody nomenclature?
Mab = monoclonal antibody
Murine (mouse derived) : “Mo” = mouse,
Chimeric (of animal derived: “xi = chimeric
Humanized (some human derived): “Zu” = humanized
Human (from human 100%): “Mu” = human
Explain how the use of murine vs humanized monolconal antibodies affect hypersensitivity.
The more animal the antibody the greater the risk for hypersensitivity. The more human the antibodies, the lesser the risk for hypersensitivity.
What is the role of monoclonal antibodies in “flagging cancer cells”?
Cancer cells gets coated with the monoclonal antibodies which makes it an easier target for destruction.
What is the role of monoclonal antibodies in “triggering cell-membrane destruction”?
MAB triggers an immune system response that can destroy the cancerous cell membrane.
What is the role of monoclonal antibodies in “blocking cell growth”?
MAB will block the connection between the cancer cells and the proteins it needs to promote cell growth.
What is the role of monoclonal antibodies in “preventing blood vessel growth”?
MAB will block the protein-cell interaction needed for the growth of new blood vessels to cancer cells.
What is the role of monoclonal antibodies in “blocking immunue system inhibitors”?
MAB can block immune inhibition resulting in more immune activity.
What is the role of monoclonal antibodies in “directly attacking cancer cells”?
MAB will attach to cancer cells, triggering the cells self-destruct processes.
What is the role of monoclonal antibodies in “delivering radiation treatment” ?
MAB are used for targeted deliver of radiation to cancer cells. (more specific)
What is the role of monoclonal antibodies in “delivery chemotherapy”?
Created as a shuttle to deliver chemotherapy directly for cancer cells while avoiding health cells.
What is the role of monoclonal antibodies in “binding cancer and immune cells”?
binding MAB to cancer cells and immune system cells to encourage the immune system to attack targeted cancer cells.
