21 Monoamine Oxidase Inhibitors Flashcards

1
Q

Onset of clinical toxicity of MAOis

A

6-24 hours after ingestion

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2
Q

True or False:
Blood levels of MAOi correlate with clinical toxicity

A

FALSE

Answer:
Clinical toxicity is usually delayed UNTIL WELL after MOST OF THE DRUG HAS BEEN METABOLIZED

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3
Q

Drugs that cannot be given if the patient is currently taking MAOis

A

Meperidine
Dextrometorphan
Tramadol
Linezolid
Propoxyphene
SSRIs
SNRIs

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4
Q

True or False:

Delayed gastric lavage for MAOi is generally not recommended

A

True

MAOis are absorbed rapidly; if presentation is WITHIN 1 HOUR, SDAC can be given. but MDAC is not recommended

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5
Q

Recommended antihypertensive agents for MAOi overdose

A

Phentolamine 2.5-5mg IV q10-15 mins
Nitroprusside 1mcg/kg/min as IV infusion

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6
Q

Recommended anticonvulsants of choice for MAOi overdose

A

Benzodiazepines (Loraz and Diaz)

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7
Q

Hallmark symptom of tyramine reaction

A

Severe occipital or temporal headache

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8
Q

There should be at least a ____-week abstinence period between the ime a MAOi is discontinued and when any contraindicated drug is started

A

2 weeks

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9
Q

Most common ECG finding for MAOi overdose

A

Sinus tachycardia

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