21 Monoamine Oxidase Inhibitors Flashcards
Onset of clinical toxicity of MAOis
6-24 hours after ingestion
True or False:
Blood levels of MAOi correlate with clinical toxicity
FALSE
Answer:
Clinical toxicity is usually delayed UNTIL WELL after MOST OF THE DRUG HAS BEEN METABOLIZED
Drugs that cannot be given if the patient is currently taking MAOis
Meperidine
Dextrometorphan
Tramadol
Linezolid
Propoxyphene
SSRIs
SNRIs
True or False:
Delayed gastric lavage for MAOi is generally not recommended
True
MAOis are absorbed rapidly; if presentation is WITHIN 1 HOUR, SDAC can be given. but MDAC is not recommended
Recommended antihypertensive agents for MAOi overdose
Phentolamine 2.5-5mg IV q10-15 mins
Nitroprusside 1mcg/kg/min as IV infusion
Recommended anticonvulsants of choice for MAOi overdose
Benzodiazepines (Loraz and Diaz)
Hallmark symptom of tyramine reaction
Severe occipital or temporal headache
There should be at least a ____-week abstinence period between the ime a MAOi is discontinued and when any contraindicated drug is started
2 weeks
Most common ECG finding for MAOi overdose
Sinus tachycardia