21: adaptive immunity

Question 1

What is MHC-1

Answer 1

presents intracellular antigen, nucleated cells must present cytosolic peptides on MHC-1:
antigen from cytosol degraded by proteasome, translocated into ER by TAP, loaded onto MCH-1 and endocytose into goggle, secreted via secretory vesicle

Question 2

What is MHC-2

Answer 2

presentare extracellular antigens, found on dendrites, macrophages, B-cells
MHC-2 assembled in ER, moves through Golgi, resides in cell, antigens phagocytose by endosome and degraded peptide antigen placed in MHC-2, brought to surface

Question 3

what are lymphoid organs

Answer 3

where MHC1- and MHC-2 are, secrete lymphocytes(T and B cells), originate in primary tissue and move to secondary tissue
lymphoid tissue: appendix, lymph nodes, spleen, tonsils

Question 4

What are CD8/CD4 cells?

Answer 4

antigens presented on MHC1 are bound to CD8 (MHC2 is CD4)
allow T and B cells to lnk w MHC

Question 5

how does APC find a match?

Answer 5

APC looks for T-cell receptor that binds antigen and activates the T-cell

Question 6

What is produced when MHC-1 binds CD8

Answer 6

1.memory cytotoxic cells that stay in lymphoid tissue and
2. cytoxic cells in the blood stream that move into blood stream to wait for cytokines

Question 7

What happens when infected cell harbored with antigen is present?

Answer 7

MHC-1 binds surface and elicits immune response and apoptosis
activated Tc cells release perforin and granzymes that kill cell

Question 8

What happens when CD8 binds naive T cell?

Answer 8

B cell binds matching antigen and internalizes the peptide to present on MHC-2
B cell presents antigen to CD$ T-Cells to confirm activation
- produced memory B cells and antibodies

Question 9

What is the function of antibodies

Answer 9

soluble B cekk receptor thats secreted by plasma cells that has antigen binding region and constant region, has CCOIN function

Question 10

What is COIN?

Answer 10

C: crosslinking,increase phagocytosis
O: opsonization increases phagocytosis (antibodies bind receptor on macrophage surface)
I: immobilization, decrease motility/adherance
N: neutralization: inactivate virulence

can also bind pilus and prevent adherence

Question 11

How to antibodies signal to phagocytosis?

Question 12

Cellular immunity intracellular infection

Answer 12

MHC-1 binds CD8-Tcell, produces cytotoxic CD8, antigen harbored within self, apoptosis

Question 13

humoral immunity

Answer 13

MHC-2 bind cd4 T cell bind naive B cell and secrete plasma cells which secrete antibodies, antibodies disable pathogens and take for removal. Phagocytes engulf and destroy opsonized pathogens