203. Microbiology of STIs

Question 1

What bugs cause Urethritis and what is unique about them?

Answer 1

1. Neisseria Gonorrhoeae: pili have antigenic variation (initial attach to epithelial cells, antiphagocytic), opa proteins anchor bacterium to host cell surface, NEED TO TX PARTNER
2. Chlamydia Trachomatis: Type III Secretion system
3. HSV: both types can cause vesicular painful tender lesions, with common recurrences

Question 2

What bugs cause Genitalia Lesions and what is unique about them?

Answer 2

1. Treponema Pallidum: TX PARTNER
2. Haemophilus Ducreyi: Chancroid and tender inguinal adenopathy
3. HSV 1/2
4. HPV - can recur

Question 3

What bugs cause vaginitis and what is unique about them?

Answer 3

1. Trichomonas vaginalis - men asx; TX PARTNER
2. Bacterial Vaginosis (gardnerella) - assoc with STD, few neutrophils
3. Yeast Vaginitis (candida) - cheesy