202-1 Flashcards
Classification of Captopril
ACE inhibitor
Mechanisms by which Captopril works:
1: inhibits change of Angiotensin I to Angiotensin II
2: Decreases aldosterone secretion (inc. sodium & water excretion)
3: Decreases peripheral vascular resistance
Common adverse effects of Captopril:
chronic cough
Serious adverse effects of Captopril:
neutropenia, fever, chest pain, hypotension, dysuria, photosensitivity, angioedema, hyperkalemia, hyponatremia, positive ANA titer
Pregnancy classification of Captopril:
D
Therapeutic class of Captopril
Antihypertensive
Pharmacotherapeutics for Captopril:
1: hypertension
2: malignant HTN when prompt titration of BP is needed
3: heart failure unresponsive to alternative treatment
4: left sided heart failure after an MI
5: diabetic nephropathy
Route of Captopril
PO
Onset of Captopril
15-60 min
Peak of Captopril
60-90 min
Duration of Captopril
6-12 hr
Captopril decreases ______ concentration in the blood
angiotensin II
Contraindications of Captopril
concurrent aliskiren use in diabetics or patients with renal impairments
Captopril may interact with:
ACE inhibitors: increased hypotension, renal impairment
allopurinol: incr. hypersensitivity reactions
antacids: decreases absorption
Digoxin: inc. digoxin levels
NSAIDS: additive effects
Alcohol: additive
Adverse reactions of Captopril:
Persistent nonproductive cough, angioedema, rash, hypotension, neutropenia, and dyspnea
____ decreases absorption of Captopril
food
What to watch for when patients are taking Captopril:
Assess blood reports for hyperkalemia, hyponatremia, and neutropenia, and assess urine for proteinuria.
Therapeutic class of Dextromethorphan
antitussive
Indications for Dextromethorphan
nonproductive cough
mechanism of action for dextromethorphan
affects the cough center in the medulla
onset of Dextromethorphan
~ 15-30 minutes
Duration of Dextromethorphan
5-6 hours
Dextromethorphan adverse effects:
toxicity, nausea, vomiting, drowsiness, dizziness, irritability
Use Dextromethorphan cautiously in:
patients with hepatic impairment, pregnant women
Contraindications of Dextromethorphan
chronic cough from emphysema or asthma
Drug-drug interactions with Dextromethorphan
other CNS depressants (increased sedation)
MAOIs (possible serotonin syndrome)
Alcohol (Additive effect)
Fluoxetine, quinidine
Food-drug interactions with Dextromethorphan
grapefruit Orange juice (increased risk of toxicity)
Important patient/family teaching for Dextromethorphan therapy
sedative effects, pregnancy
Classification of Guaifenesin
expectorant
indications for guaifenesin
cough with thick secretions and promoting productive cough
mechanism of action of guaifenesin
removes fluid and mucus from the URT by increasing volume & reducing adhesiveness and surface tension
onset of guaifenesin
30 mins
duration of guaifenesin
4-6 hours
peak of guaifenesin
unknown