2019 Flashcards
what placental enzyme breaks down betamethasone
11beta-hydroxysteroid dehydrogenase type 2
genetic anticipation
s/sx become more severe or appear earlier in subsequent generations
what happens to plasma osmolality in pregnancy
decreases to new set point, plasma sodium dec as well
Pregnancy complicated by abdominal pain, cardiac arrythmia, gastric ulcer- what hormone elevated
Parathyroid. increase in Ca and Phos. Increased Calcium leads to increased gastrin secretion and PUD
what molecule has higher net excretion in pregnancy than outside?
glucose- why! impared reabsorption in the loop of henle
Maximum dose of labetalol in 24 hours
220 mg/24 hr
maximum dose of hydralazine in 24 hours
25 mg/24 hr
when is vertical transmission of CMV highest
T3
maternal pH in DKA?
< 7.3
why peritoneal dialysis over hemodialysis ?
Less fluctuations in BP, no anticoag required
goal for initial resuscitation of patient in septic shock?
IV Abx within 1 hour
midgut herniation would not be normal after CRL of?
54mm
SGA/Nasal hypoplasia/ stippled epiphyses, hydrocephalous cataracts is associated with?/
WARFARIN EXPOSURE
TIME PERIOD FOR NEURAL TUBE CLOSER
21 to 28 days post concepction
rate of transmission of CMV after a primary infection in pregnancy
30-50%
what is best statistical test to assess your primary outcome (time to delivery) with adjustment for confounders?
cox proportional hazard curve
case control study good for?
rare outcome
what organism causes UTI in those with alkaline urine?qq
proteus
population prevalence of CF carrier in caucasian population
1/25
history of prior pregnancy with hemolytic disease of the newborn, new partner, how do you know the risk?
fetal antigen status
cell free DNA fetal antigen testing needs wHAT to be valid?
more than 6 of 92 SNPs must differ between mother and fetus, if not- repeat test in 4-6 weeks
most common structural anomalies with 22q11 del
cleft palate and interrupted aortic arch
describe chest x ray in TTN
prominent perihilar streaks which represent engorged pulmonary lymphatics and BVs
describe chest x ray in respiratory distress syndrome
low-volume lungs with diffuse reticulogranular pattern and air bronchograms
most important clinical benefit for delayed CC in preterm infant
50% decrease in IVH
characteristics of congenital rubella syndrome
deafness, cataracts, supra valvular pulmonic stenosis (pathognomic)
what interventions should you offer for pprom less than 22 weeks
latency antibiotics; no BMZ, GBS proph, mag for NP, or tocolytics
benefit of magnesium for NP?
decreases the risk of CP or death
what is the incidence of stillbirth per thousand 1 week after BPP 8/8 (modified or reg BPP)
0.8
what is the incidence of still birth per thousand 1 week after NST
1.9
LBCVA associated with?
persistent left SVC
premutation number of repeats
55-200
IHSS inheritance
AD
what hormones favor sodium excretion
progesterone (inhibits aldosterone), atrial natriuretic protein, vasodilatory prostaglandins
hormones that promote sodium reabsorption
aldosterone, deoxycortisone, estrogen
