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Revision - Path - Year 5 > 2017 paper > Flashcards

2017 paper Flashcards

1
Q

Abx for MSSA skin infection

A

Flucloxacillin

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2
Q

Abx for MRSA

A

Vancomycin

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3
Q

Listeria abx

A

Amox

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4
Q

Meningiits abx

A

Cef

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5
Q

If under 3 months or old and have meningitis

A

Add amox to cef for listeria cover

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6
Q

Encelphalitis mx

A

And acyclovir with cef

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7
Q

Sore throat IV meds

A

IV benzylpenecillin
IV metronidazole

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8
Q

Sore throat PO

A

PO Pen V = phenoxy methyl pencillin

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9
Q

Menigitis adult differentials with gram staining

A

Strep pneumoniae - g+ diplloccoci
H influenzae - gram negative bacilloccci
Neisseria meningitis = gram negative cocci

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10
Q

90 percent of encephalitis is caused by which virus gropu and viruses

A

Enterovirus - coxsackie and echovrius

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11
Q

Ribavirin is used in

A

Hep c

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12
Q

Non severe malaria treatment

A

Artemisinin combination therapy (ACT)

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13
Q

Severe malaria tx

A

Artesunate
Quinine

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14
Q

What can quinine cause in which metabolic condition

A

Quinine - can cause haemolysis in someone with G6PD

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15
Q

What is the most common cause of meningitis in a child >3m/o?

A

N meningitids

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16
Q

Oesophageal cancer in teh top / middle or in a smoker

A

squamous cell cancer (normal cells are squamous not columnar) - also in global south

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17
Q

Reflux also causes

A

adenocarcinoma

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18
Q

Where is intrinsic factor produced

A

Gastric body - hence resulting in atrophy in pernicious anaemia

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19
Q
A

H pylori can cause ADENOCARCINOMA

SEe Jule’s notes

And MALT

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20
Q
A

Coeliac - EATL

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21
Q

Types of amyloidosis

A

AL - MM
AA - systemic from chronic infection

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22
Q

List info about osteoma, osteosarcoma, Ewing’s, chondrosarcoma, adenocarcinoma

A

Osteoma - benign
Ewings sarcoma - young people
Chondrosarcoma - cartilage areas
Adenocarcinoma - most comon type of cancer
Osteoma - benign

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23
Q

Best indicator for portal hypertension

A

Splenomegaly
Caput medusae

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24
Q

Spider naevi is caused by

A

Spider naevi in the distrubtion of SVC is from oestrogen

Odema is from low albumin

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25
Q

Name a Bruton’s

A

Bruton’s = x linked gamma globulinopathy

Causing NO B CELLS as cannot produce immunoglobulin

26
Q

What is IFN gamma receptor deficiency, what does it predispose to

A

IFN gamma receptor deficiency prediposes to TB and antypical mycobacteria

IFN needed to produce granulomas

27
Q

What is common variable

A

Antibody deficiency
Failure of differentiation and fucntion of B cells
Reduction in all Igs, esp IgG

but they do have B cellls

28
Q

How do you differentiate between common variable and Brutons

A

Common variable - do get B cells but don’t work

Brutons - no B cells

29
Q

SCID

A

Recurrent infections
B cells and T cells don’t work very well = low

30
Q

Leukocyte adhesion

A

Neutrophils can’t get into the tissue, so can’t die in the tissue so you don’t get pus

31
Q

Bare lymphocyte syndrome 2

A

CD 4 low
MHC 2 not working
IgG
iGA

these two can’t be produced due to lack of class switching due to no CD4 for CD40L

32
Q

IgA def

A

2/3 not symptomatic
mucosal surfaces is normally where IgA is, hence lack of it causes resp and GI infections

33
Q

Leukocyte adhesion

A

Neutrophils can’t get into tissue
CD18 CD11 lacking

neutrophilia
all other wbcs normal

Delayed fall off of the umbilical stump

34
Q

Common variable is also associated with which autoimmune problem

A

Autoimmune thrombocytopenia

35
Q

type 3 hypersensitivity

A

C3
Ab
Ag
Immune complexes

36
Q

NK cells target which cells

A

Any cells which don’t contain MHC class 1

37
Q

Name a hereditary angioedema

A

Hereditary angioedema
ACEi exacerbates it
C1 inhibitory deficiency
Bradykinin mediated

38
Q

cd34

A

stem cells

39
Q

anti TNF

ILF17
IL 12 /23

A

Psoriasis targets

40
Q

GCA stands for

A

giant cell arteritis

41
Q

Denosumab target

A

Rank L

42
Q

ACE inhibitors can cause

A

angioedema

43
Q

Hereditary angioedema triggers

A

Food
Latex
Dental procedures

44
Q

Anti PD-1

A

Immune checkpoint inhibitors

45
Q

Myeloma qualifiers

A

Osteolytic lesion on imaging
eGFR - under 40
as soon as there’s one CRAB Symptom

46
Q

Normal eGFR

A

Over 90

47
Q

Waldenstrom’s lymphoma

A

IgM paraprotein
Hyperviscosity

48
Q

name a type of delayed transfusion reaction

A

post transfusion purpura

49
Q

How does delayed transfusion reaction present

A

Delayed haemolytic reaction would give you jaundice a few days later

within 28 days

50
Q
A

Kid and Rhesus D antigen antibody forms

51
Q

Delayed haemolytic reaction

A

Do you get a fever with delayed - yes

52
Q

immediate transfusion reaciton

A

ABO incompatibility

53
Q

What is the cause of haemolysis in HELLP syndrome

A

MAHA

54
Q

Fibrinogen does what in pregnancy

A

Goes up

55
Q

Where is folate absorbed

A

Duodenum

56
Q

Coeliac disease causes

A

Folate deficiency

57
Q

what is post thrombotic syndrome

A

bruising, venous problems after DVT

58
Q

drug used in Tumour lysis syndrome

A

Rasburicase - urate oxidase - makes uric acid more water soluble, therefore you can excrete it better

59
Q

Rasburicase taken, then haemolytic anaemia with irregularly contracted cells

A

G6PD deficiency

60
Q

Valve associated haemolytic anaemia

A

Mechanical haemolytic anaemia

Revision - Path - Year 5 (6 decks)

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