2017 paper

Question 1

Abx for MSSA skin infection

Answer 1

Flucloxacillin

Question 2

Abx for MRSA

Answer 2

Vancomycin

Question 3

Listeria abx

Answer 3

Amox

Question 4

Meningiits abx

Answer 4

Cef

Question 5

If under 3 months or old and have meningitis

Answer 5

Add amox to cef for listeria cover

Question 6

Encelphalitis mx

Answer 6

And acyclovir with cef

Question 7

Sore throat IV meds

Answer 7

IV benzylpenecillin
IV metronidazole

Question 8

Sore throat PO

Answer 8

PO Pen V = phenoxy methyl pencillin

Question 9

Menigitis adult differentials with gram staining

Answer 9

Strep pneumoniae - g+ diplloccoci
H influenzae - gram negative bacilloccci
Neisseria meningitis = gram negative cocci

Question 10

90 percent of encephalitis is caused by which virus gropu and viruses

Answer 10

Enterovirus - coxsackie and echovrius

Question 11

Ribavirin is used in

Answer 11

Hep c

Question 12

Non severe malaria treatment

Answer 12

Artemisinin combination therapy (ACT)

Question 13

Severe malaria tx

Answer 13

Artesunate
Quinine

Question 14

What can quinine cause in which metabolic condition

Answer 14

Quinine - can cause haemolysis in someone with G6PD

Question 15

What is the most common cause of meningitis in a child >3m/o?

Answer 15

N meningitids

Question 16

Oesophageal cancer in teh top / middle or in a smoker

Answer 16

squamous cell cancer (normal cells are squamous not columnar) - also in global south

Question 17

Reflux also causes

Answer 17

adenocarcinoma

Question 18

Where is intrinsic factor produced

Answer 18

Gastric body - hence resulting in atrophy in pernicious anaemia

Answer 19

H pylori can cause ADENOCARCINOMA

SEe Jule’s notes

And MALT

Answer 20

Coeliac - EATL

Question 21

Types of amyloidosis

Answer 21

AL - MM
AA - systemic from chronic infection

Question 22

List info about osteoma, osteosarcoma, Ewing’s, chondrosarcoma, adenocarcinoma

Answer 22

Osteoma - benign
Ewings sarcoma - young people
Chondrosarcoma - cartilage areas
Adenocarcinoma - most comon type of cancer
Osteoma - benign

Question 23

Best indicator for portal hypertension

Answer 23

Splenomegaly
Caput medusae

Question 24

Spider naevi is caused by

Answer 24

Spider naevi in the distrubtion of SVC is from oestrogen

Odema is from low albumin

Question 25

Name a Bruton's

Answer 25

Bruton's = x linked gamma globulinopathy Causing NO B CELLS as cannot produce immunoglobulin

Question 26

What is IFN gamma receptor deficiency, what does it predispose to

Answer 26

IFN gamma receptor deficiency prediposes to TB and antypical mycobacteria IFN needed to produce granulomas

Question 27

What is common variable

Answer 27

Antibody deficiency Failure of differentiation and fucntion of B cells Reduction in all Igs, esp IgG but they do have B cellls

Question 28

How do you differentiate between common variable and Brutons

Answer 28

Common variable - do get B cells but don't work Brutons - no B cells

Question 29

SCID

Answer 29

Recurrent infections B cells and T cells don't work very well = low

Question 30

Leukocyte adhesion

Answer 30

Neutrophils can't get into the tissue, so can't die in the tissue so you don't get pus

Question 31

Bare lymphocyte syndrome 2

Answer 31

CD 4 low MHC 2 not working IgG iGA these two can't be produced due to lack of class switching due to no CD4 for CD40L

Question 32

IgA def

Answer 32

2/3 not symptomatic mucosal surfaces is normally where IgA is, hence lack of it causes resp and GI infections

Question 33

Leukocyte adhesion

Answer 33

Neutrophils can't get into tissue CD18 CD11 lacking neutrophilia all other wbcs normal Delayed fall off of the umbilical stump

Question 34

Common variable is also associated with which autoimmune problem

Answer 34

Autoimmune thrombocytopenia

Question 35

type 3 hypersensitivity

Answer 35

C3 Ab Ag Immune complexes

Question 36

NK cells target which cells

Answer 36

Any cells which don't contain MHC class 1

Question 37

Name a hereditary angioedema

Answer 37

Hereditary angioedema ACEi exacerbates it C1 inhibitory deficiency Bradykinin mediated

Question 38

cd34

Answer 38

stem cells

Question 39

anti TNF ILF17 IL 12 /23

Answer 39

Psoriasis targets

Question 40

GCA stands for

Answer 40

giant cell arteritis

Question 41

Denosumab target

Answer 41

Rank L

Question 42

ACE inhibitors can cause

Answer 42

angioedema

Question 43

Hereditary angioedema triggers

Answer 43

Food Latex Dental procedures

Question 44

Anti PD-1

Answer 44

Immune checkpoint inhibitors

Question 45

Myeloma qualifiers

Answer 45

Osteolytic lesion on imaging eGFR - under 40 as soon as there's one CRAB Symptom

Question 46

Normal eGFR

Answer 46

Over 90

Question 47

Waldenstrom's lymphoma

Answer 47

IgM paraprotein Hyperviscosity

Question 48

name a type of delayed transfusion reaction

Answer 48

post transfusion purpura

Question 49

How does delayed transfusion reaction present

Answer 49

Delayed haemolytic reaction would give you jaundice a few days later within 28 days

Answer 50

Kid and Rhesus D antigen antibody forms

Question 51

Delayed haemolytic reaction

Answer 51

Do you get a fever with delayed - yes

Question 52

immediate transfusion reaciton

Answer 52

ABO incompatibility

Question 53

What is the cause of haemolysis in HELLP syndrome

Answer 53

MAHA

Question 54

Fibrinogen does what in pregnancy

Answer 54

Goes up

Question 55

Where is folate absorbed

Answer 55

Duodenum

Question 56

Coeliac disease causes

Answer 56

Folate deficiency

Question 57

what is post thrombotic syndrome

Answer 57

bruising, venous problems after DVT

Question 58

drug used in Tumour lysis syndrome

Answer 58

Rasburicase - urate oxidase - makes uric acid more water soluble, therefore you can excrete it better

Question 59

Rasburicase taken, then haemolytic anaemia with irregularly contracted cells

Answer 59

G6PD deficiency

Question 60

Valve associated haemolytic anaemia

Answer 60

Mechanical haemolytic anaemia