2014-03-07 USMLE Psych - USMLE Psych Flashcards
Age of onset of schizophrenia
Men 15-25
Women 25-35
Prevalance of schizoprenia
1% in most cultures
List the differences between psychotic disorders
6 month = schizophrenia
Why are atypical antipsychotics preferred for maintainence therapy in psychotic disorders?
less EPS and better effect on negative symptoms
Onset of dystonia if EPS reaction?
hours to days
Treatment of acute dystonia
- anithistamines (diphenhyd)
- anitcholinergics (benztropine, trihexyphenidyl)
Onset of akathisia if EPS reaction
within days
Treatment of akathisia
can try b-blockers
Onset of parkinsonism if EPS reaction
within months of treatment
Parkinsonism from EPS most common in
older women
Acute dystonia from EPS most common in
young men
Onset of tardive dyskinesia if EPS reaction
after years of treatment
Treatment of tardive dyskinesia
- none
- likely stop antipscyhotic and switch to atypical
Features of neuroleptic malignant syndrome
- rigidity
- high fever (up to 107)
- high CPK
- sweating
- myoglobinuria
- mutism
- altered mental status (agitated of obtunded)
Treatment of neuroleptic malignant syndrome
- stop antipsychotic
- supportive care for fever and renal
- consider giving dantrolene
classic side effect of thorazine
retinal pigment deposits
classic side effect of clozapine
agranulocytosis
Classic side effects of chlorpromazine
- jaundice
- photosensitivity
3 classic side effects of SSRIs
- insomnia
- anorexia
- sexual dysfunction
Firs line treatment of depression
therapy and SSRIs
Mechanism of action of TCAs
- NE reuptake block
- serotonin reuptake block
- a-adrenergic block
- AchM block
Why do TCAs cause orthostatic hypotension?
a-adrenergic block
MAOIs may be good for
atypical depression (eating and sleeping more)
TCA overdose most concerning for
cardiac arrhythmias
MAOIs + tyramine =
HTN crisis
Age of onset of bipolar disorder
16-30 years old
1st line agents for bipolar disorder
- lithium
- valproic acid
(carbamezapine 2nd line)
What is bipolar II?
hypomania with major depression