2 - venous thrombosis

Question 1

what is arterial thrombosis and treatment?

Answer 1

high pressure system →atherosclerosis →platelet rich thrombus

treat = aspirin & other antiplatelet drugs

Question 2

what is venous thrombosis and treatment?

Answer 2

blood doesn’t move (no damaged tissue for platelets to stick) →clotting factors just chilling so stick together making fibrin rich clot

treat = heparin/warfarin and new oral anticoagulants (drugs that target secondary haemostasis)

Question 3

what are risk factors for venous thrombosis?

Answer 3

virchow’s triad = stasis, vessel wall (damage to veins valves from previous DVT or age - means blood falls back & more stasis), hypercoagulability

Question 4

what is thrombophilia?

Answer 4

familial or acquired disorders of haemostatic mechanisms - they’re predisposed to thrombosis
either due to
1. increased coagulation activity (more clotting factors)
or
2. decreased natural anticoagulants so lots more clots (most common cause)

Question 5

what can hint to thrombophilias?

Answer 5

• venous thrombosis under 45 yrs old
• recurrent venous thrombosis
• unusual venous thrombosis
• fam history of venous thrombosis
• fam history of thrombophilia

Question 6

what is cause of acquired thrombophilia?

Answer 6

antiphospholipid antibody syndrome

Question 7

what clotting factor deficiency not associated with bleeding?

Answer 7

clotting factor XII

Question 8

what stage of pregnancy is most likely for VTE?

Answer 8

first 6 weeks postpartum