2- haemopoiesis

Question 1

what is lifespan of
a) RBC
b) neutrophil
c) platelet

Answer 1

a) 120 days
b) 7-8 hrs
c) 7-10 days

Question 2

what do myeloid and lymphoid progenitors differentiate to?

Answer 2

myeloid progenitors can differentiate to Red cells, neutrophils & platelets

lymphoid progenitors can differentiate to lymphocytes

Question 3

where do bone marrow biopsy in adult and in child?

Answer 3

posterior iliac crest in adult
- tibial in young child

Question 4

what is
a) red bone marrow
b) yellow bone marrow

Answer 4

a) haemopoietically active
b) fatty active (increases with age)

Question 5

what is myeloid:erythroid ratio?
- what should normal ratio be? why would ratio change?

Answer 5

relationship of neutrophil precursors to nucleated RBC precursors = should be more myeloid than erythroid

more myeloid than erythroid
- unless haemolysis or acute blood loss which means increased erythroid so more erythroid than myeloid

Question 6

why do RBCs develop near macrophage?

Answer 6

macrophage provides iron & nutrients

Question 7

how to identify
a) non lymphoid
b) lymphocytes

Answer 7

a) non-lymphoid cells = look under microscope

b) lymphocyte cells = look to see what antigens they express (since all look the same) →immunophenotyping