2. Types of receptors

Question 1

What is a Ligand-gated ion channel receptor?

Answer 1

An intrinsic transmembrane receptor which allows passage of ions upon binding of specific chemicals.

Question 2

Name the general steps involved in ligand-gated ion channels and an example

Answer 2

1. Binding of neurotransmitter to receptor
2. Hyperpolarisation or Depolarisation
3. Cellular effects
   eg. Nicotinic ACh receptor

Question 3

What is the timescale for ligand-gated ion channel receptors?

Answer 3

milliseconds

Question 4

Endogenous Ligands?

Answer 4

A small molecule which changes conformation upon binding.