10. Limb Development Flashcards
1
Q
Name the 3 Limb axes
A
Anterior (towards head) - Posterior (towards feet)
Proximal (towards centre body) - Distal (away from centre body)
Dorsal (front) - Ventral (back)
2
Q
Where does initial outgrowth occur?
A
the flank of mesoderm
3
Q
What is key for initial outgrowth?
A
FGF signal
4
Q
How does FGF travel and what does it bind to?
A
travels through the mesenchyme to bind to receptor proteins
5
Q
Name the axis on which the initial outgrowth occurs
A
Proximal - Distal
6
Q
What pattern does the mesoderm determine and by what signalling is it orchestrated by?
A
determines cell death pattern by BMP signalling
