2 metabolism/excretion

Question 1

general strategy of metabolism

Answer 1

to convert lipophilic into hydrophilic molecules so they can be more readily excreted

Question 2

phase 1 of drug metabolism. do all drugs need it?

Answer 2

• catabolic
• makes a more reactive metabolite by introducing/unmasking a reactive chemical group to the drug
  (if inactive, metabolised by phase 1)
• not all need it e.g. paracetamol alr has appropriate functional group

Question 3

phase 2 of drug metabolism

Answer 3

• use reactive functional group to add another molecule
• can also inactivate a drug

Question 4

phase 1 reactions are catalysed by

Answer 4

CYP450 enzymes

Question 5

? is one of the most common phase 2 conjugation reactions

Answer 5

glucuronidation

Question 6

what is freely filtered into bowman’s capsule?

Answer 6

• small solutes
• water-soluble drugs