1 absorption/distribution Flashcards
1
Q
effect of local inflammation on anaesthetics
A
delays it (because more [H+])
2
Q
IV is not suitable for ? substances
A
oily
3
Q
in the stomach what happens to weak acids and bases? intestine?
A
- in the stomach, shift to DH + H+ for weak acids so absorption favoured
- reverse for weak bases
4
Q
how to avoid first pass metabolism
A
- rectal route
- sublingual
5
Q
levels of plasma fluid, ECF and total body water
A
- plasma 3L
- ECF 14L
- total body water 42L
6
Q
binding to plasma proteins ? Vd
A
decreases because more drug binds to plasma proteins > higher [plasma] > Vd = k/concentration so Vd increases
