2 L1 Synaptic Molecular Anatomy Flashcards
What is a feature of electrical synapses that has helps with coordination of a response
Synchronising- releases molecules in synchrony
What is the role of the hypothalamus in sending information
The hypothalamus receives input from the CNS and PNS and funnels this to the pituitary
What is the role of the pituitary in sending information
Pituitary is a major communication “hub” between the brain and other organs
What is a neurite
Any projection from the cell body of a neuron
Describe the relationship between connexins and gap junctions
Connexins - Connexon - Gap junction
Compare the relative size of the 2 kinds of vesicles
Small- 50nm
Large- 100nm
Compare the relative translucency of SSV and LDCV
SSV- electron-lucent (clear)
LDCV- electron-dense (dark)
True or false- Both SSV and LDCV are membrane bound
True- they are both membrane bound
What kind of substances do SSV transport
Classical neurotransmitters- Glutamate, GABA, Glycine
What kind of substances do LDCV transport
Neurotrophins, peptide hormones
What are the primary locations of LDCV
PNS (sympathetic neurons) - Hypothalamus - Neurosecretory cells - Neuroendocrine cells
Describe Neurosecretory cells
Neurons that secrete their products into the pituitary portal vessels
Describe Neuroendocrine cells
Cells which receive neuronal input and release hormones into the bloodstream
What is the rough ratio of SSV to LDCV
99:1
Is the release of LDCV relatively slow or fast. Why
Slow because they to make their way to the active zone
What kind of receptors do LDCV act on
GPCR and tyrosine kinase receptors
Do LDCV affect pre or post synaptic cells. Explain
Both- Local diffusion to active synaptic partners. Can be synchronising or enhancing/ modulating (inhibitory or excitatory)
