2 - Drug Toxicities

Question 1

Xanthopsia (yellow vision)
Photopsia (“positive visual phenomena”)
Decr color vision
Abnormal ERG

Answer 1

Digoxin

Question 2

Crystalline deposits in macula
Macular edema
Rare now

Answer 2

Tamoxifen

Question 3

Crystalline deposits in macula

Taken to tan skin

Answer 3

Canthaxanthine

Question 4

Pigmentary deposits on K and ant lens capsule
Pigmentary retinopathy
Tx for schizophrenia

Answer 4

Thioridazine

Question 5

Decr night vision

Tx for acne

Answer 5

Isotretinoin

Question 6

Corneal whirl
Bull’s eye maculopathy
Safe dose <6.5mcg/day

Answer 6

Chloroquine/hydroxy

Question 7

CME

Answer 7

Nicotinic acid (vit A def)

Question 8

Retinal PR and GC toxicity

Tx for malaria

Answer 8

Quinine

Question 9

Normal fundus app
ERG abnormalities
VF constriction

Answer 9

Vigabatrin

Question 10

Normal fundus app
Haloes
Blue vision

Answer 10

Sildenafil

Question 11

Crystalline deposits vs exudates vs drusen

Answer 11

CD: located just on surface - on inner retinal membrane
-canthaxanthine, tomoxifen

E: in OPL

D: on PR layer