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Mycoviro (Prelim) > 2. DNA virus > Flashcards

2. DNA virus Flashcards

1
Q

Largest, Most complex DNA virus

A

Poxviridae

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2
Q

Causative agent of small pox and the first virus that was eradicated in 1976

A

Variola virus

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3
Q

Vector for introducing active immunizing genes, maybe the product of genetic recombination

A

Vaccinia

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4
Q

Example of disease in Poxviridae?

A

Monkeypox
Mousepox
Cowpox
Camelpox
Orf

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5
Q

Bacteria like that contain vaccinia: 90% protein; 5% lipid, and DNA 3

A

Poxviruses

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6
Q

In poxvirus, what are the 2 viruses that causes vertebrate infection?

A

Orthopoxvirus
Parapoxvirus

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7
Q

Viral DNA and several viral proteins within the core

A

Nucleosome

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8
Q

In poxvirus, what part of it causes irregular surface tubules?

A

Outer membrane

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9
Q

Enclosed in a lipid bilayer envelope containing virus-specific substances

A

Virion

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10
Q

What part of the host cell does Poxvirus replicate?

A

Cytoplasm

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11
Q

Poxvirus Intermiediate transcription and late transcription takes place in the?

A

Cytoplasm

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12
Q

The replication of viral DNA and synthesis takes how many hours for post infection

A

2-6 hrs

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13
Q

The Manifestation of poxvirus is can be seen in what place of the Body?

A

skin

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14
Q

What do you call the eosinophilic inclusions?

A

Guarnieri bodies

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15
Q

Where is the primary multiplication for smallpox?

A

Lymphoid tissue

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16
Q

Where is the secondary multiplication for smallpox?

A

Other organs (Liver)

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17
Q

Which part of the skin is affected by cytoplasmic inclusion by smallpox?

A

Stratum spinosum

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18
Q

When is mouth lesion ulcerate happens for smallpox?

A

6th to 9th day

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19
Q

This mark as the 2ndary acantholysis

A

Ballooning degeneration

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20
Q

What is the incubation period of Poxvirus?

A

10 to 14 days

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21
Q

In poxvirus, how many days to cause fever and malaise?

A

1 to 5 days?

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22
Q

In poxvirus, when will the crusts fall off?

A

2 weeks

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23
Q

In poxvirus, the lesion can be seen more on the ?

A

Face than the trunk

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24
Q

What is the BSL for Poxvirus?

A

BSL 4

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25
Q

What is the serology for Poxvirus?

A

Ab assays

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26
Q

When should Ab assay be done for Poxvirus?

A

1 week after using HAI, neutralization, ELISA, RINA, and IF

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27
Q

Face, arms, back that has small, pink, wart like tumors

Umbilicated papule

A

Molluscum Contagiosum

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28
Q

Molluscum Contagiosum incubation period?

A

up to 6 months

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29
Q

Molluscum Contagiosum can commonly be seen in what age group?

A

children > adults

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30
Q

HHV1 targets?

A

Waist Up

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31
Q

HHV2 targets?

A

Waist down (Genital Herpes)

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32
Q

HHV3 is also known as?

A

Varicella zoster virus

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33
Q

HHV4 is also known as?

A

Cytomegalo virus

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34
Q

HHV5 is also known as?

A

Epstein bar virus (Kissing disease)

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35
Q

Virus that is caused by Roseola infantum, Exanthema subitum

A

HHV6

36
Q

This encodes many enzymes and persists indefinitely in the infected host, spherical, icosahedral

A

Herpesvirus

37
Q

Viruse hat cause Roseola?

A

HHV7

38
Q

Virus that causes Kaposi sarcoma associated Herpes virus

A

HHV8

39
Q

In Herpesvirus, A capsid is surrounded by amorphous proteins called

A

Tegument

40
Q

tegument protein-complexes with several proteins and activates initial viral gene expressio

A

VP16

41
Q

What are the subfamily of Herpesvirus

A

Alpha
Beta
Gamma

42
Q

Subfamily of herpes, that has a short, cytolytic and the latent infections is the neurons

A

Alpha

43
Q

What are the HHV of alpha?

A

1
2
3

44
Q

Subfamily of herpes, that has a long, cytomegalic and long, lymphoproliferative with latent infections in glands, kidney, and lymphoid tissue

A

Beta

45
Q

What are the HHV in Beta?

A

5
6
7

46
Q

Subfamily of herpes, it has a Variable, lymphoproliferative with the latent infections in lymphoid tissue

A

Gamma

47
Q

What is the HHV of Gamma?

A

4
8

48
Q

Generalities of Herpesvirus, where does it reside before reactivation?

A

Sensory ganglia

49
Q

How long does it take for the replication of HSV?

A

18 hrs

50
Q

Viral DNA of herpesvirus is synthesized with what mechanism?

A

Rolling circle mechanism / replication`

51
Q

What is the HSV vrial late gene products?

A

Glycoproteins

52
Q

Proteins that is the product of immediate early genes wich stimulate transcription of early genes

A

Alpha proteins

53
Q

Protein that is the product of early genes

A

Beta proteins

54
Q

Proteins that is the product of late genes which is the viral structural proteins

A

Gamma proteins

55
Q

Most potent inducer of neutralizing antibodies of HSV glycoproteins

A

gD

56
Q

C3b-binding protein of HSV glycoproteins

A

gC

57
Q

Fc receptorl binds with Fc of IgG of HSV glycoproteins

A

gE

58
Q

type specific and allows for antigenic discrimination between HSV-1 and HSV-2 of HSV glycoproteins

A

gG

59
Q

What is the clinical infections for HSV 1 and 2?

A

Trigeminal ganglia
Sacral ganglia

60
Q

What is the latent infection forr HSV?

A

Lifetime

61
Q

An intranuclear inclusion bodies, multinucleated giant cells

A

Cowdry Type A

62
Q

Primary infection for herpes?

A

Break skin

Retrograde axonal flow to dorsal root ganglion

63
Q

Incubation period for Varicella zoster virus?

A

10 to 21 days

64
Q

Primary viremia fro Varicella zoster virus?

A

Bloodstream and replicates

65
Q

Where is the secondary viremia?

A

Liver and spleen

66
Q

Shingles commonly infect what part of the body?

A

Head, Trunk, Neck

67
Q

Most common complication in the elderly related to Shingles?

A

Post herpetic neuroglia

68
Q

An asymptomatic congenital disease is the most common cause of congenital infection with the largest genetic content of human herpesvirus?

Keratogenic

A

Cytomegalovirus

69
Q

An oncogenic lymphoproliferative virus that B cell is the main target?

A

Epstein bar virus

70
Q

Atypical lymphocytes seen in patients with mononucleosis

A

Downey cells

71
Q

Seldom causes disease in rhesus monkeys

Neurologic disease is the striking feature of this virus

A

Herpes B virus

72
Q

In the outer surface, what containcs in the inner nucleoplasmid and in viral genome?

A

HBsAG

73
Q

In the outer surface, what containcs L strand?

A

Circular DNA

74
Q

In the outer surface, what containcs S strand?

A

Minus strand

75
Q

Lipoprotein envelope, surrounds an inner nucleocapsid core particle HBcAG

A

HBsAG

76
Q

Not detectable in the serum unless the virion is treated with detergent

A

HBcAg

77
Q

Smallest of known human pathogens?

Requires HBsAg coat for transmission

A

Hepatitis D virus

78
Q

Use as a viral vector for astrazeneca vaccine?

A

Adenovirus

79
Q

What adenovirus cause Respiratory diseases?

A

Adenovirus 3, 7, 21

(3 x 7 = 21)

80
Q

What adenovirus cause Respiratory diseases?

A

Adenovirus 3, 7, 21

(3 x 7 = 21)

81
Q

What adenovirus cause GI disease?

A

Adenovirus 40 and 41

82
Q

Used as viral vector for COVID vaccines?

A

Adenovirus

83
Q

Smalles DNA animal virus that causes erythema infectiosum, Transient aplastic crisis, Pure red cell aplasia, and hydrops fetalis?

A

Parvovirus B19

84
Q

What are the 3 virus in Papovavirus

A

Papillomavirus
Polyomavirus
Vacuolating virus

85
Q

Oncogenic virus that consist warts and cervical cancer?

A

Papillomavirus

86
Q

Oncogenic virus the causes hemorrhagic cystitis and progressive mulifocal leukoenceohalopathy?

A

Polyomavirus

87
Q

A DNA virus that has the potential to cause tumors in animals but most often persist as a latent infection?

A

Simian Vacuolating virus

Mycoviro (Prelim) (8 decks)

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