2. DNA virus Flashcards by Miguel Acosta

Largest, Most complex DNA virus

Poxviridae

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Causative agent of small pox and the first virus that was eradicated in 1976

Variola virus

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Vector for introducing active immunizing genes, maybe the product of genetic recombination

Vaccinia

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Example of disease in Poxviridae?

Monkeypox
Mousepox
Cowpox
Camelpox
Orf

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Bacteria like that contain vaccinia: 90% protein; 5% lipid, and DNA 3

Poxviruses

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In poxvirus, what are the 2 viruses that causes vertebrate infection?

Orthopoxvirus
Parapoxvirus

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Viral DNA and several viral proteins within the core

Nucleosome

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In poxvirus, what part of it causes irregular surface tubules?

Outer membrane

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Enclosed in a lipid bilayer envelope containing virus-specific substances

Virion

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What part of the host cell does Poxvirus replicate?

Cytoplasm

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Poxvirus Intermiediate transcription and late transcription takes place in the?

Cytoplasm

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The replication of viral DNA and synthesis takes how many hours for post infection

2-6 hrs

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The Manifestation of poxvirus is can be seen in what place of the Body?

skin

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What do you call the eosinophilic inclusions?

Guarnieri bodies

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Where is the primary multiplication for smallpox?

Lymphoid tissue

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Where is the secondary multiplication for smallpox?

Other organs (Liver)

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Which part of the skin is affected by cytoplasmic inclusion by smallpox?

Stratum spinosum

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When is mouth lesion ulcerate happens for smallpox?

6th to 9th day

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This mark as the 2ndary acantholysis

Ballooning degeneration

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What is the incubation period of Poxvirus?

10 to 14 days

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In poxvirus, how many days to cause fever and malaise?

1 to 5 days?

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In poxvirus, when will the crusts fall off?

2 weeks

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In poxvirus, the lesion can be seen more on the ?

Face than the trunk

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What is the BSL for Poxvirus?

BSL 4

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What is the serology for Poxvirus?

Ab assays

When should Ab assay be done for Poxvirus?

1 week after using HAI, neutralization, ELISA, RINA, and IF

Face, arms, back that has small, pink, wart like tumors Umbilicated papule

Molluscum Contagiosum

Molluscum Contagiosum incubation period?

up to 6 months

Molluscum Contagiosum can commonly be seen in what age group?

children > adults

HHV1 targets?

Waist Up

HHV2 targets?

Waist down (Genital Herpes)

HHV3 is also known as?

Varicella zoster virus

HHV4 is also known as?

Cytomegalo virus

HHV5 is also known as?

Epstein bar virus (Kissing disease)

Virus that is caused by Roseola infantum, Exanthema subitum

HHV6

This encodes many enzymes and persists indefinitely in the infected host, spherical, icosahedral

Herpesvirus

Viruse hat cause Roseola?

HHV7

Virus that causes Kaposi sarcoma associated Herpes virus

HHV8

In Herpesvirus, A capsid is surrounded by amorphous proteins called

Tegument

tegument protein-complexes with several proteins and activates initial viral gene expressio

VP16

What are the subfamily of Herpesvirus

Alpha Beta Gamma

Subfamily of herpes, that has a short, cytolytic and the latent infections is the neurons

Alpha

What are the HHV of alpha?

1 2 3

Subfamily of herpes, that has a long, cytomegalic and long, lymphoproliferative with latent infections in glands, kidney, and lymphoid tissue

Beta

What are the HHV in Beta?

5 6 7

Subfamily of herpes, it has a Variable, lymphoproliferative with the latent infections in lymphoid tissue

Gamma

What is the HHV of Gamma?

4 8

Generalities of Herpesvirus, where does it reside before reactivation?

Sensory ganglia

How long does it take for the replication of HSV?

18 hrs

Viral DNA of herpesvirus is synthesized with what mechanism?

Rolling circle mechanism / replication`

What is the HSV vrial late gene products?

Glycoproteins

Proteins that is the product of immediate early genes wich stimulate transcription of early genes

Alpha proteins

Protein that is the product of early genes

Beta proteins

Proteins that is the product of late genes which is the viral structural proteins

Gamma proteins

Most potent inducer of neutralizing antibodies of HSV glycoproteins

C3b-binding protein of HSV glycoproteins

Fc receptorl binds with Fc of IgG of HSV glycoproteins

type specific and allows for antigenic discrimination between HSV-1 and HSV-2 of HSV glycoproteins

What is the clinical infections for HSV 1 and 2?

Trigeminal ganglia Sacral ganglia

What is the latent infection forr HSV?

Lifetime

An intranuclear inclusion bodies, multinucleated giant cells

Cowdry Type A

Primary infection for herpes?

Break skin Retrograde axonal flow to dorsal root ganglion

Incubation period for Varicella zoster virus?

10 to 21 days

Primary viremia fro Varicella zoster virus?

Bloodstream and replicates

Where is the secondary viremia?

Liver and spleen

Shingles commonly infect what part of the body?

Head, Trunk, Neck

Most common complication in the elderly related to Shingles?

Post herpetic neuroglia

An asymptomatic congenital disease is the most common cause of congenital infection with the largest genetic content of human herpesvirus? Keratogenic

Cytomegalovirus

An oncogenic lymphoproliferative virus that B cell is the main target?

Epstein bar virus

Atypical lymphocytes seen in patients with mononucleosis

Downey cells

Seldom causes disease in rhesus monkeys Neurologic disease is the striking feature of this virus

Herpes B virus

In the outer surface, what containcs in the inner nucleoplasmid and in viral genome?

HBsAG

In the outer surface, what containcs L strand?

Circular DNA

In the outer surface, what containcs S strand?

Minus strand

Lipoprotein envelope, surrounds an inner nucleocapsid core particle HBcAG

HBsAG

Not detectable in the serum unless the virion is treated with detergent

HBcAg

Smallest of known human pathogens? Requires HBsAg coat for transmission

Hepatitis D virus

Use as a viral vector for astrazeneca vaccine?

Adenovirus

What adenovirus cause Respiratory diseases?

Adenovirus 3, 7, 21 (3 x 7 = 21)

What adenovirus cause Respiratory diseases?

Adenovirus 3, 7, 21 (3 x 7 = 21)

What adenovirus cause GI disease?

Adenovirus 40 and 41

Used as viral vector for COVID vaccines?

Adenovirus

Smalles DNA animal virus that causes erythema infectiosum, Transient aplastic crisis, Pure red cell aplasia, and hydrops fetalis?

Parvovirus B19

What are the 3 virus in Papovavirus

Papillomavirus Polyomavirus Vacuolating virus

Oncogenic virus that consist warts and cervical cancer?

Papillomavirus

Oncogenic virus the causes hemorrhagic cystitis and progressive mulifocal leukoenceohalopathy?

Polyomavirus

A DNA virus that has the potential to cause tumors in animals but most often persist as a latent infection?

Simian Vacuolating virus