1.1 Basic Virology Flashcards
Slimy liquid, poison is a _________ Word for virus?
Latin
NOTE: VIRUS is named due to reason for the rapid spread
Who showed that a disease in tobacco was caused by a virus?
Ivanovski and Beijerinck
Who discovered an animal virus that causes foot and mouth disease in cattle?
Loeffler and Frosch
Loeffler and Frosch discovered virus that causes foot and mouth disease in what animal?
Cattle
Year of discovery for virus that causes foot and mouth disease in cattle and the tobacco was caused by virus?
1890s
Who first proposed the term Virus
Louis pasteur
True or False, Virus cannot exist independently from the host cell, so aren’t considered living things
TRUE
What is the proteins shell or the external coat of Virus?
Capsid
Lack enzymes and lack machinery ? T or F?
T
High specificity of host cell? T or F?
T
The period of time between infection by a virus and the appearance of the mature virus within the cell?
Eclipse period
What do you call a virus with no envelope?
Naked virus
Capsid + Nucleic acid?
Nucleocapsid
Fully formed virus that is able to establish an infection in a host cell
Virion
Part of the virus where it is used for attachment due to exposed glycoproteins?
Spike (Peplomers)
Covers the nucleocapsid?
Envelope
Viral capsid is made of protein molecule that is constructed from identical subunits called?
Capsomers
3 types of Viral capsid?
Helical
Icosahedral
Complex
Functionst of Viral capsid?
Protect
Help introduce DNA or RNA
Stimulate immune system
The sum total of the genetic information carried by an organism
Genome
Virus only have genes necessary to invade host cells and redirect their activity T or F?
TRUE
Parvovirus contains _____ Stranded DNA
Single
All Virus are double stranded DNA except?
Parvovirus
All Virus are Single stranded RNA except?
Reoviruses
Reoviruses are ______ Stranded RNA
Double stranded
2 types of dsDNA?
Linear
Circular
NOTE: Central dogma (Replication, Translation, Transcription)
RNA are mostly ______ Stranded
Single
Genomes that are ready for immediate translation into proteins
Positive sense RNA
Genomes have to be converted into the proper form to be made into proteins
Negative sense RNA
Individual Genes exist on separate pieces of RNA
Segmented
Example of DNA viruses that are ENVELOPED Double stranded genome?
Poxviruses
Herpesviruses
Example of DNA viruses that are NONENVELOPED Double stranded genome?
Adenoviruses (Linear)
Papovaviruses (Cirular)
Example of DNA viruses that are NONENVELOPED Single stranded genome?
Parvoviruses
Example of RNA viruses that are ENVELOPED Single stranded genome that encodes reverse transcriptase??
Retroviruses
Example of RNA viruses that are ENVELOPED Single stranded genome that are segmented?
OBA
Orthomyxoviruses
Bunyaviruses
Arenaviruses
Example of RNA viruses that are ENVELOPED Single stranded genome that are Non segmented genome?
Paramyxoviruses
Rhabdoviruses
Filoviruses
Coronaviruses
CRaF/P
Example of RNA viruses that are NONENVELOPED Single stranded genome?
Picornaviruses
Caliciviruses
Example of RNA viruses that are NONENVELOPED Double stranded genome?
Reoviruses
Suffix for families in virus?
Viridae
Classify viruses with 7 groups
David Baltimore’s Classification
What are the 7 groups?
I - dsDNA viruses
II - ssDNA viruses
III - dsRNA viruses
IV - Positive sense single stranded RNA viruses
V - Negative sense single stranded RNA viruses
VI - Positive sense Reverse transcribing RNA viruses
VII - Positive sense Reverse transcribing DNA viruses
Most are ds, show icosahdral symmetry and replicate in the nucleus
Group I, II, and VII
Only ssDNA
Parvoviridae
In group I, II, and VII, what viridae has complex DNA which can replicates in the cytoplasm?
Poxviridae
Example of dsDNA?
Herpes
Adeno
Papilloma
Pox
Polyoma
Example of ssDNA (+) sense DNA?
Parvo
Anello - No associated disease
Example of dsRNA?
Reoviridae
In reoviridae, what causes diarrhea causing virus?
Rotavirus
In reoviridae, what is used for the model for virus studies?
Reovirus
In reoviridae, what causes colorado tixk fever?
Coltivirus
in Single stranded RNA viruses (+) sense RNA, what causes severe acute respiratory syndrome COV?
Coronaviridae
Example of Picornaviridae?
Hepatovirus A
Poliovirus
Rhinovirus
Example of Calciviridae?
Norwalk
Hepatitis E
in Single stranded RNA viruses (+) sense RNA, what causes Yellow fever, west nile, Dengue, Zika, Japanese En, Hepatitis C and G?
Flaviviridae
in Single stranded RNA viruses (+) sense RNA, what causes Rubella, Chikungunya?
Togaviridae
(-)ssRNA Viruses (-) sense RNA, what causes Marburg and Ebola?
Filoviridae
(-)ssRNA Viruses (-) sense RNA, what causes Measles, Mumps, Nipah
Paramyxoviridae
(-)ssRNA Viruses (-) sense RNA, what causes RSV?
Pneumoviridae
(-)ssRNA Viruses (-) sense RNA, what causes rabies?
Rhabdoviridae
(-)ssRNA Viruses (-) sense RNA, what causes Lassa virus, Machupo virus?
Arenaviridae
(-)ssRNA Viruses (-) sense RNA, what causes Influenza?
Orthomyxoviridae
ssRNA-RT viruses (+) sense RNA with DNA intermediate in life cycle, what causes HIV?
Retroviridae
What are the process of multiplication of viruses
Adsorption
Penetration
Uncoating
Synthesis
Assembly
Release
During synthesis, this enter host cells nucleus where they are replicated and assembled
DNA viruses
During synthesis, it replicated and assembled in the cytoplasm
RNA viruses
During release, what happens to nonenveloped and complex viruses?
Released through cell lyses or ruptures
During release, what happen to the enveloped viruses?
Release through budding or excytosis
How long it takes for the entire cycle of viruses multiplying?
8 to 36 hrs
Virus induced damage to the cell that alters its mircoscopic appearance
Cytopathic effect
Viruses enter their host cell and permanently alter it genetic material, leading to cancer, this effect called?
Transformation
Viruses causes cancer
Oncoviruses
Viruses that infect bacteria?
Bacteriophage
Special DNA phages that undergo adsorption and penetration but are not replicated or released immediately
Temperate phages
The cell’s progeny will also have temperate phage
Lysogeny
When a bacterium acquires a new trait from its temperate phage
Lysogenic conversion
A chronic, persisten disease that has long period of latency and causes deposition of protein fibers in the brain tissues which are called prions
Spongiform encephalopathies
Defective form of viruses
Satellite viruses
Virus that Parasitize plants which composed only naked strands of RNA
Viroids