[2] Chemotherapy and Complications of Treatment Flashcards
How do you improve phase specific agents for chemotherapy?
Increase the exposure time
Magic number of chemotherapy cycles
6
Fractional cell killing doesn’t completely work because of what reason?
It assumes that all cells are continuously in dividing stages but some can reach a plateau stage and it won’t be effective here
Alternating chemotherapy is only effective against this sarcoma
Ewing’s Sarcoma
Define: Measurable Lesion
Lesions that can be accurately measured in at least one dimension with longest diameter
Define: Complete Response
Disappearance of all target lesions
Define: Partial Response
> = 30% decrease in Sum of Longest Diameter when compared to Baseline
Define: Progressive Disease
> = 20% increase in Sum of Longest Diameter since initiation of treatment or appearance of new lesions
Chemotherapy is a mixed contraindication to chemotherapy, which trimester is it most dangerous to give?
1st Trimester
If you had previous cytotoxic chemotherapy how much time must pass before you can have another round of chemotherapy?
No less than 2 weeks time (Bone marrow has to recover from the 12 day danger period)
Deadliest side effect of chemotherapy
Bone marrow failure
Monitoring for leukopenia and neutropenia should be done after at least how many days post-chemotherapy? Why is this so?
At least 7-10 days post-chemotherapy
Circulatory lymphocytes have a lifespan of 7-10 days
An effective treatment drug for Estrogen Receptor + BRCA
Tamoxifen
Function: Aromatase Inhibitors
Inhibits aromatase to block peripheral conversion of Androstenedione -> Estrone (No Estrone -> Estradiol)
Aromatase Inhibitors should only be given to these patients
Post-menopausal women
