2 - Bio of Aging

Question 1

long acting free radical

Answer 1

peroxynitrite

Question 2

antagonistic pleiotropy

Answer 2

the genes that are beneficial early in life (up to childbearing years) may be harmful in later life, but there is no genetic pressure to reduce that

Question 3

Hutchinson Gilford Synd

Answer 3

progeria
AD, mutation in lamin-a gene
makes it hard for things to move across the nuclear membrane
median age of death 12 yo, mostly from heart failure
accelerated atherosclerosis, no CNS or cognitive changes