2 Flashcards
What is oxidative phosphorylation?
The ATP synthesized in the electron transport chain.
90% of the ATP produced in Cellular respiration
G protein coupled receptor?
Trans membrane receptor
When activated The g-protein binds to the receptor and GDP is replaced by GTP, activating the g-protein
Activated g-protein
The g-protein dissociates from the receptor and then binds to an enzyme, activating the enzyme and signalling cellular response.
The enzyme continues to signal until the signalling molecule is no longer present and GTP is hydrolyzed into GDP
Receptor Tyrosine Kinase
Two tyrosine individually bind with a ligand and they move together to form a dimer.
Then each of the tyrosine gain a phosphate from ATP
Then proteins bind to specific tyrosine and lead to cellular response
Ligand
Signalling molecules that bind to a receptor
Phosphorylation cascade
A signal in molecule is activated
Chain of kinase proteins that become activated by phosphorylation and then causes a signal for cellular response
Calcium and ip3 signalling
G-protein activates phospholipase C which cuts PIP2 into DAG and IP3
IP3 binds to calcium channel on the ER membrane which allows calcium to flow into the cell and activate proteins leading to cellular response
cAMP signalling
G-protein binds to adynyl Cyclase which converts ATP to cAMP, cAMP acts as a second messenger activating kinase A which leads to cellular response
What is substrate level phosphorylation?
Is it how ATP is made in glycolysis and the Krebs cycle
An enzyme transfers a phosphate group from a substrate to ADP to make ATP