2-4-16-Pancreas Histology DSA (Cole) Flashcards
The ___ pancreas forms the head of the pancreas and associates with the common bile duct
Ventral
The ___ pancreas forms part of the head, body, and tail
Dorsal
By week ___, pancreatic acini develop from the ducts
12
Endocrine cells are first observed along the base of the differentiating exocrine acini by weeks ___
12-16
Each islet is supplied by afferent arterioles, forming a network of capillaries lined by fenestrated endothelial cells which is known as the ____
Insulinoacinar portal system
Where do pancreatic acini receive their blood supply?
From venules leaving the surrounding islets–> this vascular system enables a local action on the exocrine pancreas of hormones produced in the islet
This independent arterial system supples the pancreatic acini (exocrine)
Acinar vascular system
___ is formed by protein secretory acini with apically located zymogen granules
Exocrine pancreas
What are the 2 components of the islets of langerhans?
1) insuloacinar portal system
2) anastomosing cords of endocrine cells
___ is the vascular component of the islets of langerhans consisting of an afferent arteriole giving rise to a capillary network lined by fenestrated endothelial cells
Insuloacinar portal system
This component of the islets of langerhans consists of alpha, beta, delta, and F cells that each secrete their own hormone: ___
Anastomosing cords of endocrine cells
Insulin causes an increase in the uptake of glucose via ___ channels
GLUT-2
What are the actions of somatostatin?
Inhibit release of glucagon and insulin in a paracrine manner
Inhibt secretion of HCl by parietal cells, release of gastrin from EEC cells
___ inhibits somatostatin secretion and inhibits secretion of pancreatic enzymes and blocks secretion of bile by inhibiting gallbladder contractions. Its function is to conserve digestive enzymes and bile between meals.
Pancreatic polypeptide
___ stimulates the release of pancreatic polypeptide
CCK
