19.0 introduction to arbovirus

Question 1

3 main groups of arboviruses

Answer 1

flaviviruses
alphaviruses
bunyaviruses

Question 2

5 flaviviruses

Answer 2

dengue 
yellow fever 
japanese encephalitis 
murray velley encephalitis 
west nile virus

Question 3

3 alphaviruses

Answer 3

chikungunya
ross river
barmah forest

Question 4

2 bunyaviruses

Answer 4

rift valley fever

crimean congo heamorrhagic fever (ticks)

Question 5

arboviruses affecting the australiasia-pacific region

Answer 5

dengue - mainly in returned travellers
marray valley encephalitis virus - returned travellers
japanese encephalitis virus - returned travellers
chikunguya virus - returned travellers
ross river - endemic to australia
barmah forest virus - endemic to australia

Question 6

3 main clinical syndromes caused by arboviruses

Answer 6

• fever, rash, arthritis
• encephalitis
• haemorrhagic fever

Question 7

which viruses cause fever, rash, arthritis

Answer 7

alphaviruses including Chik, RRV, BFV

Question 8

which viruses cause encephalitis

Answer 8

flaviviruses including JEV, MVE, west nile virus

Question 9

which viruses cause haemorrhagic fever

Answer 9

flaviviruses including yellow fever, dengue

bunyaviruses including crimean-congo haemorrhagic fever

Question 10

main lab methods for diagnosis

Answer 10

serology
antigen detection - particularly in dengue
PCR
virus culture

Question 11

serology

Answer 11

performed on serum and/or CSF (in cases of encephaitis)

Question 12

PCR

Answer 12

on plasma, most useful early in the course of disease

Question 13

virus culture

Answer 13

cell lines, most useful early in the course of disease

Question 14

called arboviruses because

Answer 14

travel with arthropod vector - most commonly mosquitos

Question 15

arboviruseses are which type of virus

Answer 15

RNA