1.9 Enzyme inhibition

Question 1

Describe how competitive inhibitors work

Answer 1

• similar molecular shape to the substrate
  -bind to the active site to prevent the substrate from binding
• not permanent

Question 2

What is the effect of increasing substrate concentration on competitive inhibitors?

Answer 2

• the effect on the inhibitor is reduced

Question 3

Describe how non competitive inhibitors work

Answer 3

• Attach to a binding site which is not the active site
  -Breaks bonds within the protein which alters the shape of the active site
  -Substrate is no longer complementary to the enzyme so cannot bind

Question 4

what is the effect of increasing substrate concentration on non-competitive inhibitors

Answer 4

no effect as inhibitor and substrate are not competing for the same active site