1.9 enzyme inhibition

Question 1

what are competitive inhibitors?

Answer 1

binds to & blocks the active site, slows rate of binding
- similar shape to substrate

Question 2

how does substrate concentration affect the effectiveness of competitive inhibitors?

Answer 2

as substrate concentration increases, inhibitory effect decreases

Question 3

what are non-competitive inhibitors?

Answer 3

• binds to a different site on the enzyme which changes the shape of active site
• makes the enzyme non-functional since substrate doesn’t bind

Question 4

how does substrate concentration affect the effectiveness of non-competitive inhibitors?

Answer 4

no effect on inhibition level