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STEP 2 by day > 18 May Cancer/Tumor Syndromes > Flashcards

18 May Cancer/Tumor Syndromes Flashcards

1
Q

What are the common cancer locations for Lynch syndrome?

A

Colorectal
Endometrial
Ovarian
Skin

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2
Q

Inheritance of Lynch syndrome

A

Autosomal Dominant

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3
Q

Which syndrome follows the 321 rule? Describe it.

A

Lynch

Patients should have genetic testing is 3 relatives over two generation and one under age 50 have colorectal cancer

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4
Q

Which syndrome is a mismatch repair problem?

A

Lynch

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5
Q

Which syndrome has a defect on chromosome 3? What is the defect related to?

A

Von Hippel-Lindau

Suppresses angiogenesis

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6
Q

Which syndrome has hemangioblastomas?

A

Von Hippel-Lindau

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7
Q

Which syndrome is associated with a defect in chromosome 11?

A

MEN 1

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8
Q

Which syndrome involves the 3 P’s? What are they?

A

MEN 1
Pituitary
Pancreas
Parathyroid

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9
Q

Which of the syndromes involves pheochromocytomas?

A

VHL

MEN2

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10
Q

Which syndromes involve the pituitary?

A

MEN1

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11
Q

Which syndromes involve the parathyroid?

A

MEN1

MEN2

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12
Q

Which syndromes involve the medullary thyroid?

A

MEN2

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13
Q

What are the 2 cancers associated with BRCA mutations?

A

Breast and Ovarian

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14
Q

What are the neoplasms associated with Familial Adenomatous Polyposis?

A

Colorectal cancer
Desmoids and Osteomas
Brain tumors

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15
Q

What neoplasms are associated with MEN1?

A

3 P’s:

Pancreas, parathyroid, pituitary

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16
Q

What neoplasms are associated with MEN2?

A

Medullary thyroid (elevated calcitonin)
Parathyroid
Pheochromocytoma

17
Q

What neoplasms are associated with VHL?

A

Hemangioblastomas involving the medulla, retina, cerebellum
Renal cell carcinoma
Pheochromocytoma

18
Q

Which syndromes involve the pancreas?

A

MEN1

19
Q

Which syndrome is associated with the RET gene dysfunction?

A

MEN2

20
Q

Which syndrome causes increased release of calcitonin leading to amyloid deposition?

A

MEN2

STEP 2 by day (15 decks)

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