18 - Flashcards
LSD CHARACTERISTICS
THE MOST NOTORIOUS OF THE LYSERIC ACID DERIVATIVES.
semisynthetic derivative not used in therapeutic
and widely abused hallucinogen drug, known as
‘acid’.
It is probably the most active and specific
psychotomimetic known, and is a mixed agonist–
antagonist of 5-hydroxytryptamine receptors (acts by
interfering with normal serotonergic transmission).
MONOTERPENOID INDOLE ALKALOIDS - COMMON BIOGENETIC ORIGIN
sTRICTOSIDINE
How is strictosidine produced?
Condensation of seologanin with tryptamine.
There is a great structural variability motivated by various reanraangents of the monoterpene reaction.
Specific reaction
a
MONOTERPENOID INDOLE ALKALOID-CONTAINING DRUGS
Rauwolfia it is the biological raw material for the obtention of yohimbine-like alkaloid, heteroyombine- like alkaloid , dihyroindole
Names of the rearranements ctaht can be produced
Aspidosperma type
Iboga type
Both are derived from the corynanthe type.
Pharmacological activity of Reserpine AND TYPE OF ALKALOID
Antihypertensive, mild tranquilizer. Neuroleptic properties.
Monoterpenoid indole akaloid
Pharmacological activity of the tereoyohimbine- like alkaloid and name
Ajmalicine.
It ias an Vasodilator, antihypertensiv.
Indications; seniile, involution syndrome, dizziness, tinnitus. Nootropic drug.
Its similar to reserpine.
Dihydroindole alkaloid- name and type of alkaloid
Ajaline - Monoterpenoid indole alkaloid
Pharmacological activity of dihydrondole, name and type of alkaloid
It is antiarrhytmic Ajmaline and it is a monoterpenoid indole alkaloid.
Basicity of serpentine
Strongly basic
Basicity of ajmalicine
weak bases
Pharmaceutical specialities of eauwolfia and reserprine, indictations
Ruñun an d tensiocomplet, they are used to treat mild moderate hypertension
Yohimbe - alkaloids
Yohimbine, it is an aprhodisiac
Yohimbine - chemistry
1 alpha and2 alpha adrenergic receptors
antagonist.
STRYCHNOS TYPE- ALKALOID CONTAINING DRUGS
Nux vomica
Calabash curare
Alkaloid of nux vomica
It contains about 1.5-5.3% of the indole alkaloids strychnne toxic alkaloids (toxic alkaloid) and its dimethoxyderivative brucine.
Chaacteristics of .
a
Calabash curare- type of alkaloid
Strychnos tye alkaloid containing drugs
Chemical charactersitics of calabash- curare
The presence of two quaternary N atom separeted by an appropirate distance, responsible of its curare- like activity.
Curar’es action
They are muscle relaxants,
Leaf of Vinca minor – type and alkaloids
Drugs with other monoterpenoid indole alkaloids
The leaes contain more than 50 alkaloids, of them vincamine, frist isolated i, is a vasodilator drug.
Drugs of other monoterpenoid alkaloids
Vincamine and vincadifformine
Pharmacological action of vincamine
It’s is a cerebral vasodilator, it increases the cerebral blood flow. It facilitates the incorporation of oxygen in brain tissue.
