18 -

Question 1

LSD CHARACTERISTICS

Answer 1

THE MOST NOTORIOUS OF THE LYSERIC ACID DERIVATIVES.

semisynthetic derivative not used in therapeutic
and widely abused hallucinogen drug, known as
‘acid’.

It is probably the most active and specific
psychotomimetic known, and is a mixed agonist–
antagonist of 5-hydroxytryptamine receptors (acts by
interfering with normal serotonergic transmission).

Question 2

MONOTERPENOID INDOLE ALKALOIDS - COMMON BIOGENETIC ORIGIN

Answer 2

sTRICTOSIDINE

Question 3

How is strictosidine produced?

Answer 3

Condensation of seologanin with tryptamine.

There is a great structural variability motivated by various reanraangents of the monoterpene reaction.

Question 4

Specific reaction

Answer 4

a

Question 5

MONOTERPENOID INDOLE ALKALOID-CONTAINING DRUGS

Answer 5

Rauwolfia it is the biological raw material for the obtention of yohimbine-like alkaloid, heteroyombine- like alkaloid , dihyroindole

Question 6

Names of the rearranements ctaht can be produced

Answer 6

Aspidosperma type
Iboga type
Both are derived from the corynanthe type.

Question 7

Pharmacological activity of Reserpine AND TYPE OF ALKALOID

Answer 7

Antihypertensive, mild tranquilizer. Neuroleptic properties.

Monoterpenoid indole akaloid

Question 8

Pharmacological activity of the tereoyohimbine- like alkaloid and name

Answer 8

Ajmalicine.

It ias an Vasodilator, antihypertensiv.

Indications; seniile, involution syndrome, dizziness, tinnitus. Nootropic drug.

Its similar to reserpine.

Question 9

Dihydroindole alkaloid- name and type of alkaloid

Answer 9

Ajaline - Monoterpenoid indole alkaloid

Question 10

Pharmacological activity of dihydrondole, name and type of alkaloid

Answer 10

It is antiarrhytmic Ajmaline and it is a monoterpenoid indole alkaloid.

Question 11

Basicity of serpentine

Answer 11

Strongly basic

Question 12

Basicity of ajmalicine

Answer 12

weak bases

Question 13

Pharmaceutical specialities of eauwolfia and reserprine, indictations

Answer 13

Ruñun an d tensiocomplet, they are used to treat mild moderate hypertension

Question 14

Yohimbe - alkaloids

Answer 14

Yohimbine, it is an aprhodisiac

Question 15

Yohimbine - chemistry

Answer 15

1 alpha and2 alpha adrenergic receptors

antagonist.

Question 16

STRYCHNOS TYPE- ALKALOID CONTAINING DRUGS

Answer 16

Nux vomica

Calabash curare

Question 17

Alkaloid of nux vomica

Answer 17

It contains about 1.5-5.3% of the indole alkaloids strychnne toxic alkaloids (toxic alkaloid) and its dimethoxyderivative brucine.

Question 18

Chaacteristics of .

Answer 18

a

Question 19

Calabash curare- type of alkaloid

Answer 19

Strychnos tye alkaloid containing drugs

Question 20

Chemical charactersitics of calabash- curare

Answer 20

The presence of two quaternary N atom separeted by an appropirate distance, responsible of its curare- like activity.

Question 21

Curar’es action

Answer 21

They are muscle relaxants,

Question 22

Leaf of Vinca minor – type and alkaloids

Answer 22

Drugs with other monoterpenoid indole alkaloids

The leaes contain more than 50 alkaloids, of them vincamine, frist isolated i, is a vasodilator drug.

Question 23

Drugs of other monoterpenoid alkaloids

Answer 23

Vincamine and vincadifformine

Question 24

Pharmacological action of vincamine

Answer 24

It’s is a cerebral vasodilator, it increases the cerebral blood flow. It facilitates the incorporation of oxygen in brain tissue.

Question 25

Uses of vincamine

Answer 25

It is used to treat psycolocial and behavioral problems of cerebral senility; in the treaTMENT OF SEQUELAE OF CEREBROVASCULAR ACCIDENTS,

Question 26

Pharmaceutical specialities of

Answer 26

Tefanvica,