17 - Pinworms Flashcards

1
Q

What are pinworms?

A

Intestinal infection due to Enterobius vermicularis

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2
Q

Which species are hosts for pinworms?

A

Only humans (not transmitted through animal feces)

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3
Q

What is the role of animals in pinworm infestation?

A

Pinworm eggs can get on animal fur, and then a human can pet the animal and if they put their hand to mouth w/o washing it, can ingest the eggs and become infected

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4
Q

What is the pathophysiology of pinworms?

A
  • Human ingests mature pinworm eggs; ova reaches stomach and outer coating is dissolved to release larvae; larvae hatch in duodenum and mature over 1-2 months
  • Live and mate throughout large intestine attached to mucosa
  • At night, pregnant females exit anus to lay eggs, leaving about 10,000 ova on perianal skin
  • After laying eggs, females usually die (but can re-enter the individual)
  • Ova become infective w/in 6 hours of being deposited and remain infective for up to 14-20 days
  • Ova have sticky outer layer, allowing them to stick to various surfaces
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5
Q

What are the methods of transmission for pinworms?

A
  • Finger to mouth (swallowed)
  • Inhalation
  • Retroinfection
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6
Q

What are risk factors for pinworms?

A
  • Overcrowded living conditions
  • Children 5-10 y/o (uncommon in children under 2 y/o)
  • Temperate and cold climates
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7
Q

What are the signs and symptoms of pinworms?

A
  • Can be asymptomatic
  • Perianal or perineal itching (worse at night)
  • Insomnia, irritability, restlessness
  • Major infestations may cause abdominal pain, anorexia, or diarrhea
  • Less common = urinary tract and vaginal sx
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8
Q

What are red flags for pinworms?

A
  • Must have diagnosis before treatment (esp. if pregnant, under 12 y/o, and have renal or hepatic dysfunction)
  • Abdominal pain
  • Severe diarrhea
  • Bloody bowel movement or painful urination
  • Fever
  • Extremely poor appetite
  • Self-inflicted lesions from repetitive scratching
  • Suspect sexual abuse
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9
Q

What are the 3 ways to diagnose pinworms?

A

1) Inspection of perianal area – 1 hour after child falls asleep, visually examine anus w/ flashlight to observe worms
2) Scotch-tape test – first thing in the morning, press a piece of tape on perianal skin, then stick to glass slide; may be repeated several times
3) Microscopic evaluation of subungual sample (under fingernails)

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10
Q

What are the goals of treatment for pinworms?

A
  • Eradicate pinworms from px and household
  • Eliminate symptoms
  • Promote good hygiene
  • Prevent reinfection and transmission
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11
Q

How can pinworms be prevented?

A
  • Handwashing after using toilet, after scratching perianal area, and before and after eating/preparing food
  • Keep nails short and discourage nail biting
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12
Q

What are some non-pharms to recommend for pinworms?

A
  • Shower every morning
  • Wash bed sheets, towels, and underwear in hot water daily for 2 weeks
  • Wash hands and clean fingernails frequently
  • All family members should wear cotton underwear during day and night and change twice daily (for 1 week after tx)
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13
Q

Who should be treated for pinworms?

A

Infested individual and all household members/close contacts (unless contraindication for medication)

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14
Q

What is the OTC treatment for pinworms? What schedule is it and why?

A
  • Pyrantel pamoate

- Schedule 2 b/c family members need to be treated after 1 diagnosis has been made

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15
Q

What is the MOA of pyrantel pamoate in patient friendly language?

A

Paralyzes the pinworms, so they no longer stick to intestinal wall and then are carried out of the patient in the stool

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16
Q

What is the dosing for pyrantel pamoate?

A
  • For adults and children over 1 y/o – single oral dose of 11 mg/kg, repeat in 2 weeks (max. single dose of 1 gram)
  • Take any time of day, w/ or w/o food
17
Q

Why is pyrantel pamoate dosed twice?

A

Because it doesn’t kill the eggs, so give time for eggs to grow and then dose again

18
Q

What are common SE of pyrantel pamoate?

A
  • N/V
  • Tenesmus (straining when passing a bowel movement)
  • Anorexia
  • Diarrhea, abdominal cramps
19
Q

Which drug does pyrantel pamoate interact w/?

A

Piperazine

20
Q

What are contraindications for pyrantel pamoate?

A
  • Hypersensitivity to drug or any ingredients
  • Avoid in 1st trimester
  • Caution in hepatic impairment
21
Q

What is the Rx treatment for pinworms?

A

Mebendazole

22
Q

What is the MOA of mebendazole?

A

Inhibits glucose uptake by helminths, so inhibits larval development

23
Q

What is the dose of mebendazole?

A

For adults and children 2 years and older - single dose of 100 mg, repeated in 2 weeks

24
Q

What are SE of mebendazole?

A
  • Abdominal pain or diarrhea
  • Anorexia
  • Flatulence
  • Vomiting
  • Neutropenia
25
Q

Which drugs does mebendazole interact w/?

A
  • Metronidazole
  • Carbamazepine
  • Phenytoin
  • Cimetidine
26
Q

Can pyrantel pamoate and mebendazole be used in breastfeeding?

A

Yes

27
Q

What are the monitoring parameters for pinworms?

A
  • Patient monitor daily for perianal itching and adverse effects of medication (N/V, diarrhea, dizziness, drowsiness)
  • Pharmacist follow up 1 day after tx regarding SE and 7 days after tx regarding perianal itching
28
Q

What are some referrals after treatment?

A
  • If not resolved w/in 7 days of second course
  • If adverse effects interfere w/ functioning or last for more than 3 days (N/V, diarrhea) or more than 1 day (dizziness, drowsiness)
29
Q

What are the symptoms of hookworms?

A
  • Mild epigastric pain and tenderness
  • Headache
  • Fatigue
  • Anemia
  • Hypoproteinemia
30
Q

What are the symptoms of roundworms?

A
  • Abdominal discomfort
  • Abdominal obstruction
  • Vomiting
  • Right upper quadrant pain
31
Q

What is the tx for hookworms?

A
  • Mebendazole 100 mg BID for 3 days

- Pyrantel pamoate 11 mg/kg (max. 1 g) per day for 3 days

32
Q

What is the tx for roundworms?

A

Mebendazole 100 mg BID for 3 days

33
Q

What are the symptoms of tapeworms?

A
  • Range form mild epigastric or abdominal pain to a burning sensation
  • General weakness
  • Weight loss
  • Headache
  • Constipation, diarrhea
34
Q

What is the tx for tapeworms?

A

Praziquantel