16 - Nails Flashcards
Anatomy of the nail
Nail Plate: Hard, translucent, dead keratin
Nail fold: surrounding skin and matrix
Matrix: Matrix epithelium synthesizes the nail plate
Lunula (white 1/2 moon): distal aspect of nail matrix, continuous w nail bed
Nail bed: consists of parallel longitudinal ridges w small blood vessels at their base
Hyponychium: short segment of skin lacking nail cover
Pic on slide 5
What is the MC effect of psoriasis on the nail?
Pitting (MC)
What effects does psoriasis have on the nail?
Pitting (MC)
Onchyolysis
Oil spots
Gross deformity (fragmentation, crubmling, and splinter hemorrhages)
What is onchyolysis?
Onycholysis is the painless separation of the nail from the nail bed.
This is a common problem. It can be a sign of skin disease, an infection or the result of injury, but most cases are seen in women with long fingernails.
Treatment for psoriasis?
Systemic:
- cyclosporin
- methotrexate
- aceitretin
Topical
- intralesional kenalog
- calcipotriol ointment (vit D)
- tazaroten gel (retinoid)
- anthralin ointment (MOA UKN)
If a pt has nail lichen planus (LP)?
They prob have it elsewhere too
- 25% have it more places
MC findings for LP?
Longitudinal grooving and ridging
Inflammation of the matrix with LP may cause?
Adhesion of the proximal nail fold to the scarred matrix (pterygium unguis)
LP tx?
Self limiting but:
Local
- intralesional kenalog
Systemic
- oral prednisone
What types of drugs effect the nail?
Chemotherapy drugs are associated w variety of changes in the nail unit
Tetracycline abx can also do it
Tinea of the nails is aka?
Tinea unguium
- its is a type of onchomycosis
Presentation of tinea unguium?
May occur simultaneously w hand/foot tinea or alone
Thickened yellow nails
- may look like psoriasis too
How to confirm onchomycosis?
KOH and CX to confirm species before treating
Cx - crumbling debris from under distal edge
Patterns of infection for oncychomycosis?
Distal subungual onychomycosis
White superficial onchomycosis
Proximal subungual onchomycosis
Oral Treatment for onychomycosis?
Oral agents
- Terbinafine (lamisil) 250mg q Day x 12 wks
- itraconazole (sporanox) 200mg q day x 12 wks
- fluconazole: 450 q week x 3 months
- griseofulvin (Gris-PEG)
Preferred txt for onchomycosis?
Terbinafine
- higher cure rate
- slower relapse rate
- not many drug interactions
- results last >2 yrs
Topical tx for onychomycosis?
Ciclopirox nail lacquer (PENLAC)
- for use w/o lunula involvment
- complex implementation
Efinaconazole (jublia)
- shitty cure rate (16-53%)
Prevention for onchomycosis?
Shoes/boots - protect toes from trauma Dont pick nails Rotate footwear Clean socks Shower shoes Keep nails short
What is chronic exposure (in reference to nails)
Repeated water immersion or Frequent use of nail polish removers
Leads to brittle nails
Chronic exposure txt?
Rehydrate the nail Moisturizer/lubricant Protective gloves Nail enamel weekly B-complex vitamin (biotin B7)
Types of nail trauma
Oncholysis Nail biting Hang nail Ingrown toenail Subungual hematoma Habit-tic deformity
What is a hangnail?
Skin separation form lateral nai folds
- esp during winter months
Txt for hang nail?
Cut separated skin before it extends
Use moisturizers
Avoid repeated hand immersion in water