16) Anti-Parkinson's

Question 1

Parkinson’s disease

Answer 1

• Brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination

Question 2

Drugs used in parkinsonism

Answer 2

• Dopamine precursor (levodopa)
• Dopamine agonists (bromocriptine, pramipexole)
• MAO inhibitors (selegiline)
• COMT inhibitors (entacapone)
• Muscarinic antagonists (benztropine)

Question 3

DCC inhibitors are used to

Answer 3

• Preserve L-dopa in the circulation until it enters the BBB

- Needed to generate dopamine in the BBB