15.7 Structure of skeletal muscle Flashcards

1
Q

What are the 3 type of muscle in the body
What do they do

A

Cardiac muscle is found only in the heart

Smooth muscle is found in the walls of blood vessels and the gut

Skeletal muscle makes up most muscle in vertebrates, it is attached to bone and we consciously control it.

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2
Q

What are muscles made of

A

Myofibrils are tiny muscle fibres.
On their own they’re very weak and can snap however when there are loads they are very powerful, like how a rope works.

Myofibrils are arranged to line up parallel to maximise their strength, and these are grouped into muscle

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3
Q

Why wouldn’t muscles work if they were made up of individual cells

A

If they were made of individual cells joined end to end it wouldn’t be able to contract very efficiently.
Junction between adjacent cells would be a weakness point which would reduce the overall strength of the muscle.

So instead these separate cells have been fused into muscle fibres which share nuclei and cytoplasm called sarcoplasm

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4
Q

What is sarcoplasm

Where is it within a muscle fibre

A

Muscle fibres share nuclei and their cytoplasm is called sarcoplasm.

Sarcoplasm is mainly found around the circumference of the fibre.
There is a high concentration of ER and mitochondria in it

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5
Q

What two myofibrils is a muscle fibre made of

A

Two types of protein filament:

Actin and myosin

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6
Q

Describe structure of actin

Describe structure of myosin

A

Actin is thinner and consists of two strands twisted around each other

Myosin is thicker and consists of long rod shaped tails with bulbous heads that project to the side

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7
Q

Myofibrils appear striped due to alternating light coloured and dark coloured bands.

How

A

As Actin is thinner than Myosin, bands only containing actin are lighter as thin and thick filaments don’t overlap.

Dark bands are where myosin and actin overlap

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8
Q

What are isotropic bands (I bands)

What is in the centre of them

A

The light bands are called I bands, which appear lighter because thick and thin filaments don’t overlap in that region.
There is only actin present there, no myosin.
These I bands surround the A band.

In the centre of I bands, is the Z line

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9
Q

What does the Z line contain

A

It has only myosin so is a lighter colour than the A bands which contain both myosin and actin.

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10
Q

What are A bands (anisotropic bands)

What is found at the centre of each A band

A

These are the dark bands where actin and myosin filaments overlap.

The H zone is found here, where it is a light coloured region.

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11
Q

What are sarcomeres

What do they do

A

Distance between two Z lines

When muscles contract these sarcomeres shorten

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12
Q

What is tropomyosin

A

Protein found in muscle, which forms a fibrous strand around actin filament

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13
Q

What are slow twitch muscle fibres

A
  • Contract more slowly than fast twitch
  • Provide less powerful contractions but over a longer period
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14
Q

What are slow twitch muscle fibres designed for

A

Endurance eg running a marathon

They are common in calf muscles and back in humans which are contracting constantly to maintain body in upright condition

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15
Q

What respiration occurs mostly in slow twitch muscles

A

Aerobic so these slow twitch fibres help avoid a build up of lactic acid which would cause muscle to function less effectively and prevent long duration contraction

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16
Q

How are slow twitch muscles adapted for aerobic respiration and slow contractions

A
  • Lots of myoglobin (which is a red molecule that stores oxygen) so there is loads of oxygen available for aerobic respiration
  • Rich supply of blood vessels to deliver oxygen and glucose for respiration
  • Lots of mitochondria to produce ATP for energy to contract the muscles
17
Q

What are fast twitch muscle fibres

A
  • These contract rapidly and produce more powerful contractions but only for a short period.
18
Q

What are fast twitch muscle fibres good for

A
  • They are therefore adapted to intense exercise eg sprinting or weightlifting
  • More common in muscles that need to do short bursts of energy eg biceps in upper arm
19
Q

How are fast twitch muscle fibres adapted to their role

A
  • Thicker and more numerous myosin filaments
  • High concentration of glycogen which can release glucose for respiration when needed
  • High concentration of enzymes involved in anaerobic respiration which provides ATP rapidly
  • Store of phosphocreatine which rapidly generates ATP from ADP in anaerobic conditions so provide energy for muscle contraction
20
Q

What is a neuromuscular junction

A

It is where motor neuron meets a skeletal muscle fibre

There are many neuromuscular junctions along the muscle fibre so a wave of contraction can travel more quickly so all fibres contract simultaneously.

Action potential can simultaneously stimulate all fibres to make muscle contract

21
Q

What is a motor unit

A

All muscle fibres are simultaneously stimulated by action potential from motor neuron, so act as a functional unit called motor unit

If only slight force is needed, a few units are stimulated. If a large force is needed, many units are stimulated

22
Q

Describe what happens when nerve impulse is received at neuromuscular junction

A
  • synaptic vesicles fuse with presynaptic membrane and release acetylcholine
  • This acetylcholine diffuses across synaptic cleft to postsynaptic membrane where it binds to receptors
  • This alters its permeability to sodium ions Na+ which enter rapidly, depolarising the membrane
  • The acetylcholine is broken down by acetylcholinesterase to ensure that the muscle is not over-stimulated. The resulting choline and acetyl diffuse back into neuron where they are recombined to form acetylcholine using energy provided by mitochondria found there.
23
Q

What are the similarities between neuromuscular junction and synapse

A
  • Both have neurotransmitters that are transported by diffusion
  • Have receptors that bind to neurotransmitter to cause influx of sodium ions
  • Use a sodium potassium pump to re- polarise the axon
  • Use enzymes to breakdown the neurotransmitter
24
Q

Differences between neuromuscular junction and cholinergic synapse

A
  • Neuromuscular junction is always excitatory whilst synapse can also be inhibitory
  • Neuromuscular junction links neurons to muscles whilst cholinergic synapse links neurons to neurons or neurons to other effector organs
  • Only motor neurones are involved in NJ but motor, sensory and intermediate neurons are involved in cholinergic synapse
  • Action potential ends at NJ but a new action potential may be produced at cholinergic synapse
  • Acetylcholine binds to receptors on membrane of muscle fibre in NJ whilst it binds to receptors on postsynaptic membrane in cholinergic synapse