15 Consideration with HIV Combination Louie

Question 1

What is the DHHS recommended NNRTI based regimen?

Answer 1

EFV/TDF/FTC

Question 2

What is the DHHS recommended Boosted PI based regimen?

Answer 2

ATV/r + TDF/FTC. OR. DRV/r + TDF/FTC

Question 3

What is the DHHS recommended II based regimen?

Answer 3

RAL + TDF/FTC

Question 4

Which drug should be avoided in pregnancy?

Answer 4

EFV

Question 5

Which drug needs HLA-B*5701 testing and why?

Answer 5

ABC. Hypersensitivity reaction

Question 6

What are the most favorable patients for NNRTIs?

Answer 6

Want maximum simplicity (1 pill QD). Concerns about renal function (when combined w/ TDF/FTC)

Question 7

If someone has a job that requires concentration, what should be avoided?

Answer 7

EFV. CNS effects

Question 8

Which NNRTI isn’t recommended for irregular meals?

Answer 8

RPV

Question 9

Which NNRTI isn’t recommended with PPIs or H2 blockers?

Answer 9

RPV

Question 10

In the study comparing three different treatment options, which one showed the best results?

Answer 10

EFV + 2 NRTIs > LPV/r + 2 NRTIs, EFV + LPV/r

Question 11

What patients are more favored for the Boosted PI based regimen?

Answer 11

Prefer not to deal with CNS ADRs. Might become pregnant. Prefer once-daily dosing

Question 12

When is the Boosted PI based regimen less favorable?

Answer 12

Diabetes. Hyperlipidemia at baseline. Concerns about renal function. Taking other drugs metabolized by CYP system. Might have an issue with potential or jaundice or scleral icterus (ATV)

Question 13

When is the II based regimen preferred?

Answer 13

Maximum simplicity (EVG). Prefer not to deal w/ ADRs associated w/ other regimens. Need concomitant drugs w/ interactions with other antiretrovirals (RAL). Concerns about CV risk. Do not mind BID dosing (RAL)

Question 14

When is the II based regimen less favorable?

Answer 14

Concerns about second daily dose (RAL). Concerns about adherence. Concerns about cost of medicine