146-147b pituitary pathology

Question 1

manifestations of hypothalamic disease?

Answer 1

hypopituitarism

disorders Vasopressin

hyperprolactinemia

Question 2

Kallmann’s syndrome

Answer 2

mutation for protein that helps migration of GnRH and olfactory neurons from olfactory placode

low GnRH (thus low FSG, LH, testerone, sperm)
anosmia

lack of secondary sexual characteristims

Question 3

what usually causes precocious puberty?

Answer 3

central - early gondotropin secretion

Question 4

what can cause hyperprolactinemia?

Answer 4

prolactin-secreting pituitary adenomes

decreased dopamine to lactotrophs (antipsychotics)

Question 5

pituitary transciption factor mutations?

Answer 5

Pit-1

PROP-1

Question 6

what hormones are affected 1st with nonfunctioning macroadenomas?

Answer 6

GH>LH/FSH>ACTH/TSH

Question 7

Sheehan’s syndrome

Answer 7

ischemic infarct of pituitary following postpartum bleeding

usually presents with failure to lactate (hypoprolactinemia)

Question 8

empty sella syndrome

Answer 8

atrophy or compression of pituitary, often idiopathic, common in obese women

Question 9

GH deficiency cause in children? adults? presentation?

Answer 9

idiopathic

pituitary tumor

fat, low muscle, low energy, shitty QOL

GH treatment effective