14 - CNS Flashcards
1) LSD works on which receptors?
2) ANtidepressants work which receptors?
1) 5HT (serotonin) receptors
2) NA and 5HT receptors
Function of NA in CNS? (3 things)
- Arousal (amphetamines)
- Mood (Depression cured by NA reuptake inhibitors)
- BP regulation
1) Describe the pathways of Acetylcholine in CNS
2) Causes of alzheimers, parkinson’s, and huntingtons?
Either:
- Pons to thalamus + cortex
- Magnocellular forebrain nucleus to cortex
- Septohipoocampal.
- Magnocullular forebrain nuclei degeneration = Alzhiemers
- Corpus straitum interneurons = Parkinson’s + Huntington’s
Descrine ACh effects in CNS
- Aoursal and attention
- Leanring + memory (AChE inhibitors treat Alzheimer’s and Anticholinergic causes amnesia)
- Motor control (anticholinergics treats parkinsons)
Describe dopaminergic pathways in CNS
Either:
- Nigrostriatal – Regulate motor control (Most of DA in brain)
- Mesolimbic/mesocortical - emotion + rewards
- Tubero-hypophyseal – Regulate secretions (hypothalamus to pituitary gland)
Dopamine functions?
- Secretions (DA inhibits secretions, can be used to treat mother’s who don’t need to lactate anymore)
- Emotions + rewards (DA antagonist = antipsychotics)
- Motor control (L-Dopa is DA agonist)
- Vomiting (DA antagonist inhibits vomiting)
Describe Serotonergic pathways in CNS
SImilar to NA, Cell bodies in pons + upper medulla near raphe (so called raphe nuclei). Project to cortex, limbic, hypothalamus, and spinal cord.
Serotonin functions?
- Mood regulation
- Sleep regulation
- Apetite and digestion
- Cognition
- Pain perception
- Cardiovascular function
- Migraine regulation
1) GABA is excitatory/inhibitory?
2) Particularly abundant where?
1) Inhibitory
2) Nigrostriatal system
Describe GABA receptors.
Drugs Tx what?
GABA A – Postsynaptic ligand-gated ion channel:
- Diazepam = muscle relaxant
- Zopiclone = insomnia
- Pregabalin = anxiety
GABA B – GPCR (pre- and post-synaptic):
- Baclofen = Spasticity
