1.3 Treatment depression Flashcards

1
Q

Waar gaat artikel Cuijpers (2016) over?

Cuijpers et al. (2016)

A

Effects of CBT on:
- MDD
- Generalized anxiety disorder (GAD)
- Panic disorder (PD)
- Social anxiety disorder (SAD)

Wordt alleen op MDD gefocust ofc.

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2
Q

How are the effects of CBT overestimated?

Cuijpers et al. (2016)

A
  1. Publication bias: the choice of journals to accept a submitted manuscript by an author, depending on the strength and/or findings.
  2. Quality of trails is not good
  3. Waiting list control groups are often used, however, the improvement in these patients have been reported to be less than expected.
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3
Q

Nocebo

Cuijpers et al. (2016)

A

Opposite of placebo.

The waiting list could develop negative expectations, therefore people believe that their symptoms worsen or do not improve during this period. The anticipation of lack of improvement could lead to more negative (health) outcomes.

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4
Q

Welke 3 resultaten komen naar voren bij Cuijpers 2016?

Cuijpers et al. (2016)

A
  1. 44.4% of the MDD vs, CBT studies were based on waiting list control groups, which resulted in a significant larger effect size than people with normal care or pill placebo control groups.
  2. CBT is ‘probably’ effective in the treatment of MDD, GAD, PD, SAD, with the effects being larger in waiting list control groups, compared to conservative control groups like care as usual and pill placebo.
  3. Due to the small number of high qualilty studies, the effects are still uncertain.
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5
Q

Waar gaat 2e artikel Cuijpers over (2019)?

Cuijpers et al. (2019)

A

Common factors and psychotherapy outcomes.

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6
Q

Common factors

Cuijpers et al. (2019)

A

Factors all therapies have in common, like:
- expectation,
- patient’s understanding of what their problem is and
- what can be done about them,
- and the alliance between the therapist and patient.

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7
Q

Dodo Bird Verdict

Cuijpers et al. (2019)

A

In 1936, Rosenzweig stated his observation about therapies.

This states that there were comparable effects of all therapies that don’t significally vary from each other.

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8
Q

First common factors model (Jerome Frank)

Cuijpers et al. (2019)

A

Four nonspecific factors that were common to all therapies and the elements that were believed to be effective in these therapies:
1. Functioning relationship between client and therapist.
2. Explanation that lends credibility to the administered treatment.
3. Specific procedures and routines presented in an organized fashion.
4. Therpeutic environment

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9
Q

Contextual model

Cuijpers et al. (2019)

A

Therapist and patient have to create bond to work together. After this bond, therapy works in 3 pathways:
1. Real relationship: connection between patient and therapist (has a therapeutic effects on patient).
2. Expectations or hope: therapy teaches patient how to deal with problems + gives them hope that they are able to undertake essential responsibility to complete therapy.
3. Distinct elements of therapy: this creates expectations in patients, activate the second pathway, and also produce some beneficial actions. (this could improve interpersonal therapy, encourage positive thinking (CBT) etc.)

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10
Q

Categories common factors

Cuijpers et al. (2019)

A
  • Support
  • Learning
  • Action

These are based on the order of change that is believed to happen during therapy (assumption, not yet confirmed)

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11
Q

How many % can be attributed to common factors and how many to specific factors?

Cuijpers et al. (2019)

A

30% = common factors

15% = specific factors

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12
Q

Bona fide therapies

Cuijpers et al. (2019)

A

Therapies delivered by trained therapists.

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13
Q

Non-bona fide

Cuijpers et al. (2019)

A

Are intended to be ineffective. They are used to compare a specific therapy model (bona fide) to a control that mimics the therapeutic setting without meeting bona fide criteria.

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14
Q

Research allegiance

Cuijpers et al. (2019)

A

The strong belief that one treatment is better than the other and believing that the theory begind the treatment is superior.

When researchers prefer a specific therapy, they might set up or interpret the study in a way that shows their chosen therapy as better than others.

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15
Q

Component studies

Cuijpers et al. (2019)

A

They break down multicomponent theories (crucial part of research).

If there is a difference between a therapy with or without a component, then the particular component is responsible for the effects of the intervention.
- Supporters of common factor model believe that there will be no difference between studies with or without a specific component.

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16
Q

Component studies

Dismantling studies

Cuijpers et al. (2019)

A

Compare full therapy with one where a component is excluded

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17
Q

Component studies

Additive studies

Cuijpers et al. (2019)

A

An extra component is added to an existing therapy.

18
Q

Active components in therapy

Cuijpers et al. (2019)

A

Specific or nonspecific factors within therapy
- Mechanisms of change
- Extratherapeutic factors
- Moderators
- Mediatiors

19
Q

Active components

Moderators

Cuijpers et al. (2019)

A

Characteristics that affect the relationship between treatment and the outcome’s direction

19
Q

Active components

Mechanisms of change

Cuijpers et al. (2019)

A

Show how and why change occurs.
- These are outcomes of active components

19
Q

Active components

Extratherapeutic factors

Cuijpers et al. (2019)

A

External events that can influence the mechanism of change, like life events

20
Q

Active components

Mediators

Cuijpers et al. (2019)

A

Statistically explain the relationship between treatment and outcome.

21
Q

Therapeutic alliance

Cuijpers et al. (2019)

A

Most important factor, stronger the alliance, better the outcome.

3 components:
1. Relationship between therapist and patient
2. Agreement on the aims of therapy
3. Agreement about the tasks of therapy.

22
Q

2 andere belangrijke common factors

Cuijpers et al. (2019)

A
  1. Expectations the patient has of the outcome
  2. Therapist empathy
23
Q

Conclusion

Cuijpers et al. (2019)

A
  • Not enough evidence for causal role specific factors
  • No sufficient evidence that specific factors are key element of how cognitive behavioural therapy works.
  • Remains unclear if factors that bring about change are specific, non-specific, or both.

Conclude: psychotherapy is very complex process in which a lot of elements probably interact with each other.

24
Q

Waar gaat artikel Undurraga over?

Undurraga (2017)

A

Effectiveness antidepressants (TCAs, SSRIs)

25
Q

2 hypotheses in this article:

Undurraga et al. (2017)

A
  1. Will be little difference between antidepressant types.
  2. Improvement in depression ratings among participants assigned to either TCA or SSRI within the trials would not show sign changes, but the participant number in the trials and the duration of the trials would increase. SSRIs could lead to lower dropout rates.
26
Q

What are 6 results of this study?

Undurraga et al. (2017)

A
  1. Nonsign variance in the responses given to SSRI and TCA
  2. Little difference in the short-term efficacy of both drugs.
  3. Responses were not related to trial size, proportion of women participants, mean drug dose or initial depression ratings.
  4. Trial duration and size increased sign
  5. More dropouts with TCAs
  6. Lager efficacy with lower dropout rates
27
Q

Waar gaat artikel Piet et al over?

Piet et al. (2011)

A

Effectiveness mindfulness based cognitive therapy (MBCT) for relapse prevention in patients with recurrent MDD in remission.

28
Q

During MBCT:

Piet et al. (2011)

A

Group intervention program (groups of 8 to 15)

8 sessions

29
Q

Theory and goal of MBCT

Piet et al. (2011)

A

Theory: people who had depression are more cognitively sensitive to low mood. The heightened sensitivity is due to mildly negative emotional states, triggering negative and ruminative thinking patterns.

Goal: to teach patients to be aware of and handle their thoughts, emotions and bodily sensations using mindulness exercises.

30
Q

What are 4 results of Piet?

Piet et al. (2011)

A
  1. MBCT is effective intervention for relapse prevention in recurrent MDD
  2. MBCT benefited individuals who had 3 or more MDD episodes the most –> because these individuals are prone to ruminative thinking.
  3. Higher relapse rate for patients with only two episodes –> stressfull life events were more often linked to relapse in pat with only 2, MBCT might not be effective to reduce relapse triggered by stressful life events.
  4. MBCT is low cost intervention
31
Q

Waar artikel Lemmens over?

Lemmens et al. (2020)

A
  • Whether efficacy of IPT/CT treatment surpassed that of waitlist.
  • Whether IPT or CT demonstrated superiority over the other in decreasing depressive symptoms
32
Q

Results in IPT vs. CT:

Lemmens et al. (2020)

6

A
  1. Sign improvements in depression severity for IPT and CT.
  2. Reponse to therapy sign higher than in the waitlist.
  3. Increased quality of life, social and general psychological functioning
  4. No sign differences between IPT and CT.
  5. Reduction of symptoms mainly maintained during the follow-up period for both IPT and CT.
  6. Pathway through which change occurs appeared to differ (IPT triggers different mechanism than CT)
33
Q

Which treatment works for whom?

Lemmens et al. (2020)

4

A
  1. Depression severity did not affect treatment type and outcome.
  2. Pat with comorbid anxiety were more likely to dropout in both treatment types.
  3. Comorbid personality disorder did not affect tretament outcome.
  4. Pat with cluster A (lack of emotional response) and/or cluster B (intense emotional response) did sign better in CT
34
Q

Predictors associated with lower depression symptoms at end of treamtent

Lemmens et al. (2020)

A
  1. Female gender
  2. Absence of personality disorder
  3. Low anxiety
  4. High quality of life
  5. Active employment

Regardless of perceived intervention

35
Q

Better response IPT

Lemmens et al. (2020)

A

Cognitive problems

36
Q

Better response CT

Lemmens et al. (2020)

A
  • Somatic complaints
  • Paranoid symptoms
  • Interpersonal self-sacrificing tendencies
  • Number of stressful life events experienced in past year
  • Attributional style focused on goal achievement
37
Q

How does IPT work?

Lemmens et al. (2020)

A

Improving interpersonal functioning

It’s theorized that treatment is effective through shared factors like motivation and therapeutic alliance instead of specific theorized mechanisms.

38
Q

How does CT work?

Lemmens et al. (2020)

A

Changing the content, function and structure of thought and schemas associated with depressive mood.