123 - Depression Flashcards

1
Q

Key aspects of history taking in suspected depression

A

History of depression
Mood elevation
Previous treatments
Nature of social network

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2
Q

Core symptoms of depression

A
Depressed mood
Anhedonia
Reduced energy
Tiredness after minimal effort
Lasted at least 2 weeks
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3
Q

How does depressed mood change in depression

A

Varies little from day to day
Diurnal variation (worse AM)
Unresponsive to circumstances

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4
Q

Other symptoms of depression

A
Impaired concentration
Reduced self esteem
Ideas of guilt and unworthiness
Pessimistic about future
Ideas/acts of self harm/suicide
Disturbed sleep
Diminished appetite
Irritability
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5
Q

Physical symptoms of depression

A
Anhedonia
Early morning wakening
Lifelessness or agitation
Weight loss
Loss of libido
Loss of emotional reactivity
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6
Q

What is mild depression

A

2 core symptoms + 2 others

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7
Q

What is moderate depression

A

2 core symptoms + 3-4 others

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8
Q

What is severe depression

A

2 core symptoms + >4 others. Can include psychotic symptoms

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9
Q

Psychotic symptoms associated with depression

A

Delusions of sin, guilt, poverty, imminent disaster,
Hypochondira
Auditory hallucinations - defamatory or accusatory
Olfactory hallucinations of faeces or rotting flesh
Severe retardation or stupor

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10
Q

What do 70% of patients with depression present with

A

Physical symptoms only

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11
Q

Symptoms of anxiety

A
Foreboding
Physical symptoms
Dry mouth
Palpitations
Dizziness
Sweating
Butterflies
SOB
Choking
May develop into panic attacks
Feeling life isn't real
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12
Q

If depression present - also need to consider what?

A

Anxiety. Closely linked and rarely present separately.

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13
Q

When prescribing anti-depressants need to take into consideration

A

Overdose toxicity.

May need to increase level of support to patient

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14
Q

Epidemiology of depression
How common
High risk groups

A

4th leading cause of disability and disease worldwide. In UK - 1/10 men and 1/4 women will need treatment for depression at some point. Mean age of onset 27 but elderly, adolescents and those with chronic diseases at more risk

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15
Q

Hopelessness depression model

A

Stressor (bad event)
Attributes blame, infers consequences and inferences about self - feels cannot do anything to change it.
Hopelessness

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16
Q

Theory of stress vulnerability

A

The more vulnerable you are, the less stresses are needed to trigger depression. If remove some stresses or increase resilience then can improve threshold for depression.

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17
Q

Remission from depression classes as

A

Absence of depressive symptoms for 2 months.

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18
Q

How long does depression generally last?

A

6-8 months. If relapse - more likely to be more severe in future.

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19
Q

What is Beck’s triad

A

How you think about:
World
Future
Self

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20
Q

How efficient is CBT at treating depression

A

Can be more effective than antidepressants over long-term

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21
Q

How does CBT work

A

Underlying model - events trigger thoughts
Thoughts influence feelings, responses and actions.
CBT acts to teach the patient how to intervene to think things through and change their thoughts

22
Q

When is ECT used

A

To treat severe depressive illness where suicide is a high risk. Usually course of 8-10 treatments with response after 2-3

23
Q

What non-drug therapies can be useful for depression?

A
CBT - increasing levels - individual guided self help, computerised CBT, structured group therapy.
Interpersonal therapy
Behavioural therapy
Relationship therapy
ECT
24
Q

Commonly prescribed antidepressants.

A

SSRIs as less side effects and equally effective as others. Antidepressants are non-addictive.

25
Side effects of antipsychotics
Weight gain, reduced glucose tolerance, affect lipid levels.
26
When giving lithium to augment antidepressants need to
Monitor renal and thyroid function. Consider ECG monitoring as affects blood viscosity.
27
Treatment for mild depression
On presentation: Assess risk Lifestyle interventions Watchful waiting - review in 2 weeks. Drugs have poor risk:benefit on presentation
28
SSRIs - Examples, when to give and side effects
Citalopram, Sertraline, Fluoxetine. Give for 6 months after resolution of depression for first treatment or 2 years if recurrence. Mainly GI issues but also hyponatraemia
29
What is hyponatraemia
Drowsiness, confusion, convulsions
30
Tricyclic antidepressants. | Examples
Amitryptilline, Butryptilline
31
Tricyclic antidepressants. | How do they work
Inhibit serotonin and noradrenaline reuptake
32
Tricyclic antidepressants. | Side Effects
Cardiotoxic (especially in overdose). | Dry mouth, blurred vision, sedation, poor concentration
33
Tricyclic antidepressants. | Contraindications
Epilepsy and heart disease
34
Use of monoamine-oxidase inhibitors
e.g. Phenylzine Inhibit breakdown of MAO neurotransmitters (e.g. serotonin) Use only in severe depression
35
How does synaptic transmission work
Action potential - Na+ floods into neutron. Ca2+ gates open so Ca2+ floods in and binds to vesicle. Vesicles mature and release neurotransmitters into synapse. NTs diffuse across synapse and bind post synaptic receptors. Na+ gates opens - floods in - starts new action potential
36
Key drug targets for neurotransmitters
``` Neurotransmitter synthesis/release Post synaptic reception Presynaptic reception Reuptake Degredation ```
37
What are ionotrophic receptors
Ion channels. Ligand binding either opens or prevents opening of channel
38
What are metabotropic receptors
Receptors where ligand binding affects intracellular signalling pathways
39
Glutamate
Excitatory neurotransmitter. Main excitatory NT of CNS | Hyper stimulation can cause seizures, inhibition can cause sedation.
40
Glycine
Inhibitory NT. Inhibited by strychnine
41
GABA
General inhibitory neurotransmitter. Hyperstimulation causes sedation while inhibition causes hyper excitability and seizures
42
Serotonin
Located in gut and brainstem (Raphae nuclei). Involved in depression, appetite, nausea and sleep.
43
Where is dopamine found?
Located in midbrain. Found in substance nigra - involved in movement (destroyed in Parkinsons) and Ventral segmental area - involved in motivation, reward and novelty.
44
Disorders of dopamine
Schizophrenia Parkinsons Tourettes
45
Noradrenaline
Found in brainstem, acts on sympathetic system. Involved in attention and arousal. Targeted by adrenaline, ritalin, TCAs.
46
Opioids
Located in hypothalamus. Involved in analgesia and reward. | Neuromodulators - affect release and effect of other neurotransmitters.
47
Acetylcholine
NT located in basal forebrain (involved in memory and cognition) and the brainstem (involved in arousal and sleep). Binds to nicotinic (ionotropic, excitatory) and muscarinic (metabotropic) receptors.
48
Loss of acetylcholine is involved in
Alzheimers disease
49
What is dysthmia
Has up to 1 core symptoms of depression and 3 total symptoms of depression
50
What is the first line treatment for depression after MIs
Setraline.
51
Treatment for depression and anxiety
Amitriptyline is best choice.
52
Side effects of TCAs
Can't see Can't pee Can't shit Can't spit