12. Malabsorption Disorders

Question 1

A wide range of defects occurring during digestion and absorption of food and nutrients in the G. I. Tract.

Answer 1

Malabsorption

Question 2

What is the actual offending agent in celiac disease?

Answer 2

Gliadin

Question 3

A patient presents with diarrhea and bloating with weight loss. Stool sample show steatorrhea and exam shows significant malabsorption of multiple nutrients.

Answer 3

Celiac Disease

Question 4

What is gold standard for celiac diagnosis?

Answer 4

Endoscopic biopsy of the small intestine

Question 5

A serological study for screening celiac disease (but not diagnosis).

Answer 5

tTG-IgA antiendomysial antibodies test

Question 6

Celiac tx

Answer 6

Total elimination of gluten

Question 7

A common BOARD associated manifestation w/Celiac disease.

Answer 7

Dermatitis Herpetiformis

Question 8

If a patient with celiac has being doing well on a gluten-free diet and suddenly becomes a non-responder, what could be going on?

Answer 8

Intestinal Lymphoma

Question 9

Testing for tropical sprue

Answer 9

O & P testing 3x (-)

Question 10

Tropical Sprue Tx

Answer 10

Gluten-free diets DO NOT improve

Tetracycline x 6 mo + folic acid supplementation

Question 11

People who typically have short bowel syndrome.

Answer 11

1) 1/2 small intestine removed
2) sig. damage of small intestine
3) poor motility

Question 12

Med for short bowel syndrome

Answer 12

Gattex (Teduglutide)

W/ H2 blockers/PPIs, hypomotility agents, supplements

Question 13

Antibiotics tx for bacterial overgrowth

Answer 13

Metronidazole (Flagyl)-ETOH!
Cipro

*May require ongoing intermittent tx.