1.2 haemoglobin

Question 1

structure of haemoglobin 1

Answer 1

Has quaternary structure AND is conjugated (protein with an non protein group).

Question 2

structure of haemoglobin 2

Answer 2

it is made up of 4 connected polypeptide subunits linked by bonds between R groups of the polypeptide chains.

Question 3

structure of haemoglobin 3

Answer 3

Each subunit has prosthetic group (non-protein group) called haem it is tightly bound to the protein is essential for its function (iron in haemoglobin is the binding site of oxygen)

Question 4

chain effect

Answer 4

Each haem group can bind one oxygen molecule

• Binding of one oxygen molecule increases affinity of remaining haem groups for Oxygen

Question 5

conformational change

Answer 5

Caused by conformational change to protein when each oxygen binds which increases the affinity of the remaining subunits for o2 the same is true in reverse

Question 6

effect of PH and temp

Answer 6

Decreased pH decreases affinity (respiring tissue produces more co2 which is acidic) / increased pH increases affinity

• Decreased temp increases affinity (respiring tissue such as muscles rises heat) / increased temp decreases affinity

Question 7

PH effect named

Answer 7

Decreased affinity caused by decreased pH is known as the Bohr effect.