12- BPD and ASPD Flashcards

1
Q

Origins of BPD

A

Origins in the psychoanalytic tradition

  • Hypersensitive, rigid, feelings of inferiority, deep insecurity, use of projection mechanisms, difficulty with reality testing, experienced negative reactions in therapy
  • Between the border of the psychoses (out of touch with reality) and neuroses (emotional) => view continued for decades (“pseudo-neurotic schizophrenia”)
  • Typically referred to patients who were challenging to treat

Kernberg (1976) described the “borderline personality organization” => Reliance on primitive defense mechanisms ex: “splitting” (all good vs. all bad)

=> BPD introduced to DSM-III in 1980 with specific criteria developed:

  • Intense affect
  • Impulsivity
  • Relationship problems
  • Psychotic experiences

“Borderline” => Provides no descriptive info about the dx (Name still strongly linked to psychoanalytic tradition)

=> WHO’s International Classification of Diseases (ICD-10) uses the term “Emotionally Unstable Disorder” *Much more accurate description

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2
Q

BPD DSM-5 Criteria

A

A pervasive pattern of instability of interpersonal relationships, self-image, and affects, and marked impulsivity, beginning by early adulthood and present in a variety of contexts

Need FIVE or more of nine sx:

  • Frantic efforts to avoid real or imagined abandonment
  • A pattern of unstable and intense interpersonal relationships
  • Identity disturbance
  • Impulsivity in at least two areas that are potentially self-damaging
  • Recurrent suicidal beh, gestures, or threats, or self-mutilating beh
  • Affective instability due to a marked reactivity of mood
  • Chronic feelings of emptiness
  • Inappropriate, intense anger, or difficulty controlling anger
  • Transient, stress-related paranoid ideation or severe dissociative sx
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3
Q

Core clinical Features: Instability with Emotions

A

Emotions change rapidly and repeatedly (“mood swings”) => Felt VERY intensely

  • Often prolonged duration
  • Slow return to baseline
  • Heightened sensitivity and reactivity to
    env stressors (little things)
  • Experience range of negative emotions (ex: Anger, sadness, shame, fear, disgust)

“Emotional Switching” => Switching between negative states ex: Anxiety to anger/Sadness to anxiety

=> From positive to negative state, or vice versa: Frequency vs. magnitude* which reflects dichotomous thinking / splitting (good vs. bad) *Not necessarily specific to BPD though (ex: BN, PTSD)

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4
Q

Core clinical Features: Instability with Relationships

A

Emotional instability is often triggered by loss, rejection, disappointment => Trigger is interpersonal (bcz of fear of abandonment)

  • Volatile relationships, lots of conflict
  • Unstable representations of others => “Splitting”: Idealized view vs. anger (pedestal to completely bad)
  • Afraid of being dependent (in case they are abandoned)
  • “Testing” significant others => leads to disappointment

Interpersonal Regulation Strategies => Interaction with another person serves an emotion regulation function

Two relevant strategies:

  • Reassurance seeking (neg reinforcement)
  • Venting

=> Useful in short-term but consequences in long-term:

  • Interpersonal (relationship difficulty)
  • Intrapersonal (more distress)
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5
Q

Core Clinical Features: Instability with Sense of self

A

Shift between no sense of self vs. many conflicting selves => Fragile and negative self-concept

  • Persistent sense of “emptiness” (diff being alone)
  • “Self-fragmentation” => No continuous sense of self across time
  • Lack clear boundary between self and other (ppl pleasing = diff beh)
  • Relationships are a high priority => Threat to relationships = threat to sense of self
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6
Q

Core clinical Features: Instability with Beh

A

Very impulsive => Typically driven by emotion (positive and negative)

Range of impulsive beh:

  • High rates of alcohol, substance abuse
  • Spending sprees
  • Risky sexual behaviors
  • Gambling
  • Binge eating
  • Non-suicidal self-injury
  • Suicide risk
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7
Q

NSSI, Suicide and BPD

A

Non-Suicidal Self-Injury (NSSI) => Dx criteria for BPD (Used to be thought of as an indicator of BPD but Now recognize it is not necessary nor sufficient for BPD)

  • VERY common in BPD => Variable prevalence rates (65-90%)
  • Mistakenly viewed as attention-seeking beh => Lay people and clinical contexts have negative attitudes toward NSSI
  • Key function of NSSI = Emotion regulation

Suicidality

  • Suicidal ideation VERY common – almost all will report
  • Suicide attempts: Estimates as high as 70% => Often multiple attempts (average 3 attempts), Ambivalent? (don’t know how serious it is)
  • 8-10% die by suicide
  • Whereas threats and ideation peak in early course of dx, the mean age of death by suicide is age 37 so Suicide doesn’t occur when therapist is most alarmed
  • VERY hard to predict who is at high risk of going from ideation to attempt

Suicidal Threats => Verbal statement or beh act that may indicate serious intent to kill oneself (Interpersonal component)

  • Common in BPD populations
  • Presents a challenge for clinicians to determine actual risk
  • Most often triggered by interpersonal relationships (ex: feeling abandoned) => Attempt to pull in another person in whatever way they can to alleviate distress
  • Viewed by others as demanding and manipulative But, likely serves an emotion regulation function

*Caution: Link between suicidal threats and attempts

How to handle chronic suicidality?

  • Hospitalization? => But, no clear tx are actually provided (“Suicide watch”, “Safety management”) => useful for psychotic breaks
  • Consider function of suicide for BPD: Escape from distress, Interpersonal communication of distress
  • Joel Paris: Hospital setting might inadvertently positively reinforce suicidality => Leads to “psychiatrization”, rather than learning life skills
  • Recommendation to manage suicide an outpatient basis
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8
Q

Epidemio

A

Prevalence: 1-2% => Higher in clinical settings (10-20%)

  • Higher rates among women => But biases in gender expectations may account for a lot of this

=> Diagnosis in adolescence?
- Cons: personality still developing, stigma
- Pros: interventions in adolescence are beneficial

=> Course:

  • BPD thought to be chronic (stable PD)
  • But many improve with appropriate tx
  • Often more severe in younger pop

Comorbidity

  • Very high (rarely ever dx alone)
  • Comorbid with other PDs: Schizotypal, narcissistic, and dependent PD especially
  • Comorbid with both internalizing and externalizing dx: MDD, PTSD, anxiety, substance use, eating disorder (ex: bulimia), bipolar

A variant of depression? Chronic form?
A variant of PTSD? Due to role of trauma?

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9
Q

Dissociation

A

Up to 75% report “psychotic-like symptoms” ex: Hallucinations, paranoid ideas, dissociation

  • But, not the same as in psychotic dx =>Typically more insight (not delusional)
  • Theorized to occur in response to
    stress *Indicated in DSM criteria

2 types:

  • Depersonalization (separate from your body)
  • Derealization (detached from the external world/ppl/objects)

Study: with BPD, clinical controls (CC), and healthy
control (HC) doing an ecological momentary assessment (EMA) => Provide hourly ratings of stress and dissociation for 48 hours

  • All groups showed association between stress and dissociation
  • But, effect strongest for BPD
  • BPD have more dissociative experiences
    (frequency and intensity) => Also present under relatively low levels of stress
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10
Q

Negative Early Life Experiences and Attachment

A

Childhood trauma, abuse, and neglect play a large role => BPD tend to report more trauma compared to controls

Studies:

  • Female patients in ER who were sexually abuse during childhood were 5x more likely to have BPD dx
  • Only 6.1% of BPD had NO history of childhood trauma => Whereas 61.5% of controls had NO such history
  • Caution warranted with retrospective recall => But similar findings with prospective reports
  • BUT, trauma is not a dx-specific risk factor => Trauma increases risk for most forms of psychopathology

Insecure Attachment => Develop internal models of self and others through attachment with primary caregiver

  • Self: acceptable, lovable, worthy
  • Others: responsive, available, supportive

=> Consistently find relationship between BPD and insecure attachment styles = Can explain many features of clinical presentation: ex: clinginess, proximity checking, intolerance of being alone

*Oscillation between Preocuppied and Fearful-Avoidant

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11
Q

Mentalization

A

Process by which we understand ourselves and others in terms of mental states => Acquire this capacity through attachment with caregiver

  • BPD = failure of mentalization
  • Mediates link between attachment and emotion dysregulation outcomes

Non-Mentalization Modes:

  • Teleological: Inferring another person’s state of mind
    based on their actions (don’t call so don’t love me)
  • Psychic Equivalence: Equating internal states with reality (i think she rejected me so she for sure did)
  • Pretend Mode: Mental world is decoupled from reality (disconnect from own mental states)
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12
Q

Biosocial Theory

A

Had BPD herself and developed theory and therapy (DBT) to help others with similar difficulties

  • Core problem in BPD: emotion dysregulation => Arises from combination of vulnerable biology and invalidating social env

Vulnerable Biology:

  • High sensitivity
  • High reactivity
  • Slow return to baseline

=> Assumption is that emotional vulnerability is biological (people are born like this) and Also refers to biological basis of impulsivity

Invalidating Social Env

  • Problems arise when caregivers consistently and persistently fail to validate their child’s emotional exp => Results in failure to learn how to identify, label, and regulate own emotions
  • Transactions between personal vulnerability and env

=> Etiologically heterogeneity

  • High biological + Low invalidation
  • Low biological + High invalidation
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13
Q

ASPD Historical Perspect and DSM-5 Criteria

A

Historical Perspectives

  • Cleckley: comprehensive description of psychopathy in 1940s => Beh features: impulsivity, antisocial beh, sexual deviancy, and irresponsibility + affective and interpersonal traits: egocentricity, superficial charm, lack of empathy

DSM-III (1980) first includes Antisocial Personality Dx

  • Strong emphasis on objectively measured beh criteria
  • Affective/interpersonal traits not included in criteria
  • Goal: improve diagnostic reliability

Criteria

A pervasive pattern of disregard for and violation of the rights of others, occurring since age of 15, as indicated by 3+ sx:

  • Failure to conform to social norms with respect to lawful beh
  • Deceitfulness
  • Impulsivity or failure to plan ahead
  • Irritability and aggressiveness
  • Reckless disregard for safety of self or others
  • Consistent irresponsibility
  • Lack of remorse

Plus:

  • Individual is at least 18 years of age
  • Evidence of conduct dx with onset before age 15
  • Sx bring them into conflict with society (ex: incarcerated)

Very beh definition => DSM doesn’t tell us about underlying personality features + Also results in very heterogeneous clinical presentation

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14
Q

Conduct Dx

A

4 Core Cat

  • Aggression to people and animals => often bullies, has used a weapon to intimidate others, has been physically cruel to animals
  • Destruction of property => deliberately engaged in fire setting, deliberately destroyed property
  • Deceitfulness or theft => stealing non-trivial items, lies to obtain things
  • Serious violation of rules => ignores curfew, often truant from school (before age 13)

Specifiers

  • Childhood-onset type (prior to age 10)
  • Adolescent-onset type (no sx prior to age 10)

Other specifiers: With limited prosocial emotions

  • Lack of remorse or guilt
  • Callous, lack of empathy
  • Unconcerned about performance
  • Shallow or deficient affect

=> Boys 4X more likely to be dx & Girls dx at a later age

Gender differences in aggression

  • Men: Physical
  • Women: Relational

=> Assortative mating: Associated with more severe negative beh, conflict, poor parenting, Kids have high genetic vulnerability + chaotic environment

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15
Q

Psychopathy

A

Cleckley advanced view that psychopath appears normal on the surface => But under the mask is a very fundamental, severe deficit

  • More psychologically-than beh- focused
  • Criminal behavior is only one potential piece
  • Can be successful, law-abiding citizen

=> Out of 16 criterias: Absence of nervousness or psychoneurotic manifestations + general poverty in major affective reactions

Psychopathy Checklist (PCL): 20-item checklist that’s rated via interview and any available records (school, police, prison)

  • Hare also emphasizes that not all psychopaths are criminal => Best career path: Business
  • PCL widely used in North America ex: Parole decisions often rely on PCL scores But criticized for not assessing lack of anxiety/fear

*Factor Structure of PCL:

  • Factor 1: Interpersonal/Affective (map + to psychopathy)
  • Factor 2: Social deviance (map + to ASPD)
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16
Q

Features Associated with Psychopathy and ASPD vs Psychopathy

A
  • More violence and aggression, severe crimes => But often get reduced sentences and likely to get released but High reoffending rates
  • But also noncriminal psychopaths => Higher rates in corporate samples
  • Ability to detect vulnerable people they can manipulate

ASPD vs. Psychopathy

  • ASPD focuses on observable beh
  • Psychopathy includes reference to emotional and interpersonal factors => Factor 1 of PCL distinguishes
  • Only small portion of individuals dx with
    ASPD are psychopathic
  • BUT, most people who are psychopathic would qualify for ASPD diagnosis

=> Psychopathy as more extreme form of ASPD? ASPD misses non-criminal psychopathy

17
Q

Epidemio

A

ASPD

  • 2-3% lifetime prevalence in general pop
  • 3-5x more common in men *recall dx bias
  • Higher rates in criminal settings
  • Higher rates also in hospital settings

Psychopathy

  • No epidemiological studies estimating prevalence
  • Hare estimates about 1% in North America
  • Over-represented in prison settings => Especially maximum-security
18
Q

Etiology: Prenantal & Birth Factors & Genes

A

Pregnancy and birth factors

  • Low birth weight
  • Malnutrition (possible protein deficiency) during pregnancy
  • Lead poisoning
  • Mother’s use of nicotine, marijuana, alcohol, other subs during pregnancy

=> No direct causal link between these factors and conduct problems has been established

  • Many possible paths linking smoking to conduct problem
  • Smoking might alter neurotransmitter systems
  • Smoking affects birth weight, and birth weight affects conduct problems

Genes

  • Family studies reveal aggregation of externalizing disorders ex: ADHD, SUD, ASPD
  • Data from adoption and twin studies suggest at least moderate genetic contribution

What is inherited?

  • Antisocial traits
  • Aggressiveness
  • Impulsivity
  • Callous and unemotional tendencies

MAOA Gene => Degrades neurotransmitters (ex: Dopamine, Norepinephrine, Serotonin)

  • More MAOA = more degradation = lower levels of NTs (associated with depression)
  • Less MAOA = less degradation = higher
    levels of NTs (associated with impulsivity and aggression)

Childhood maltreatment is a robust risk factor for conduct problems => But, most children who are maltreated do not go on to engage in significant criminal beh in adulthood

=> Different susceptibility to the experience of maltreatment with gene-env interaction

Low MAOA* + childhood maltreatment (none/probable/severe*) most likely to develop ASPD

19
Q

Etiology: Env and Sociocultural

A

Both retrospective and prospective reports associate negative upbringing (ex: abuse) with antisocial and psychopathic traits => BUT hard to separate genetics from parenting

Passive rGE:

  • Parent give antisocial genes and also give more chaotic environment (ex: maltreatment, neglect)

Evocative rGE:

  • Parents often lack psychological/physical resources to deal with difficult children
  • Results in more inconsistent discipline

Active rGE:

  • Antisocial individuals prefer to associate with similar others – miss opportunities to learn prosocial beh
  • Early criminality / drug use can eliminate future opportunities

Sociocultural Influences

  • Poverty and neighborhood crime are related to delinquency

Possible mechanisms?

  • Social cause: living in poverty increases rates of delinquency
  • Social selection hypothesis: people with psychopathology drift down to poverty
  • Work with children indicates causal association between poverty and disruptive beh, with parent supervision as mediator

=> Some evidence that collectivistic cultures have lower rates than individualistic cultures (Antisocial beh associated with minority status in North America, but this is likely due to low SES)

20
Q

Fearlessness Hypothesis

A

ASPD and psychopaths thought to be “fearless” => Higher threshold for feeling fear + Don’t show usual fear conditioning response

Is this specific to physical punishments?

Also find they are indifferent to social punishments

Evidence from startle reflex:

  • Defensive response
  • Magnitude is increased when person is fearful
  • Present people startle probe (ex: noise or image) and measure eye blink response

Study:

Presented neutral (ex: lamp), positive (ex: babies), and negative (ex: gun pointed at you) images

  • Groups did not differ in self-report of emotional response to images
  • Psychopaths did not display the typical potentiation of startle to the negative image (don’t blink)
21
Q

Tx

A

Treatment is a challenge => Without distress, little
motivation to change

  • ASPD or psychopathy results in poorer tx outcomes for substance use
  • Some weak evidence that SSRIs reduce aggressive beh and increase interpersonal skills

Building a better psychopath?

  • Some tx are effective at reducing rates of reoffending among criminal offenders
  • However, these treatments can actually cause rates of reoffending to increase for psychopaths
  • Treatments that emphasize training in social skills may actually be useful in helping psychopaths become better at charming or conning future victims
  • CBT interventions recognized as most effective (ex: increase self-control, anger management) But often fails to generalize outside of tx context