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H&C Week 3-4 > 12-2 L3 Response to Vessel injury > Flashcards

12-2 L3 Response to Vessel injury Flashcards

1
Q

Define primary vs secondary hemostasis

A
  • Primary: rapid formation of platelet ‘plugs’ at sites of injury
  • Secondary: formation of thrombus (clot)
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2
Q

List 3 inhibits that exist to prevent unnedded activation

A
  • Antithrombin and endogenous heprains
  • TPFI (tissue factor pathway inhibitor)
  • Proteins C & S
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3
Q

List 3 components of primary hemostasis

and the diseases that could effect them

A
  • Platelet
    • thrombocytopenia
    • qualitative platelet defect
    • aspirin
  • VWF
    • von willebran disease
  • Vessel wall
    • Ehlers-Danlos syndrome
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4
Q

Name key platelet structs

cellular receptors

A
  • cellular receptors
    • glycoproteins: used for adhesion to areas of endothelial damage
    • G-protein coupled receptors: that activate/recruit platelets to the platelet plug
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5
Q

Key platelet structures

SCCS

(surface connected canalicular system)

A
  • SCCS
    • Connected to the plasma membrane
    • Allows rapid internalization/externalization of membrane proteins
    • allows ofr rapid excretion of granular contents
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6
Q

Key platelet structures

Dense tubular system

A
  • Remnants of MK endoplasmic reticular system
  • Sequesters Ca important for platelete activation
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7
Q

Alpha granules

  • what do they contain
A
  • conatin proteins involved in
    • coagulation
    • inflammation
    • wound repair
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8
Q

Dense delta granules

A
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9
Q

where is vWF produced

where is it stored

A
  • produced
    • endothelial cells and MKs
  • stored
    • Veibel-Palade bodies
    • granules in platelets
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10
Q

what cleaves vWF

A

ADAMTS-13

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11
Q

What serves as a anchor point from vWf to the platelet cytoskeleton?

A
  • GP Ib/V/IX
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12
Q

GP IV binding to collagen initaitos what?

A

signaling via

  • phospholipase C and DAG/IP3
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13
Q

what does endothelial cells make?

A

VwF and F8

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14
Q

What is the first step in primary hemostasis?

A
  • Vasoconstriction
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15
Q

interiptoin of the endothelium exposes what?

A
  • Tissue factor
  • collagen (subendothelial collagen)
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16
Q

What is the most common inherited bleeding disorder

A

Von Willebrand Disease

17
Q

What is seen on a Ristocetin co factor activity test

  • normal plasma
  • vWF-deficient plasma
A
  • normal plasma: aggregation
  • vWF deficient plasma: no aggregation
18
Q

Prolong PT only (extrinsic pathway)

A
  • hereditary 7 def
  • liver disease
  • warfarin us
  • vita k def
19
Q

Prolonged PTT only (intrinsic pathway)

A
  • hemophilia A, B, or C
  • contact factor def (12, PK, HMWK)
  • Lupus anticoagulant
  • vWD (2N, 3)
  • Heparin
20
Q

Prolonged PT & PTT

A
  • warfain use
  • liver disease
  • vit K def
  • DIC
  • hypodysfibrinogenemia

H&C Week 3-4 (12 decks)

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