12-2 L3 Response to Vessel injury Flashcards
1
Q
Define primary vs secondary hemostasis
A
- Primary: rapid formation of platelet ‘plugs’ at sites of injury
- Secondary: formation of thrombus (clot)
2
Q
List 3 inhibits that exist to prevent unnedded activation
A
- Antithrombin and endogenous heprains
- TPFI (tissue factor pathway inhibitor)
- Proteins C & S
3
Q
List 3 components of primary hemostasis
and the diseases that could effect them
A
-
Platelet
- thrombocytopenia
- qualitative platelet defect
- aspirin
-
VWF
- von willebran disease
-
Vessel wall
- Ehlers-Danlos syndrome
4
Q
Name key platelet structs
cellular receptors
A
-
cellular receptors
- glycoproteins: used for adhesion to areas of endothelial damage
- G-protein coupled receptors: that activate/recruit platelets to the platelet plug
5
Q
Key platelet structures
SCCS
(surface connected canalicular system)
A
- SCCS
- Connected to the plasma membrane
- Allows rapid internalization/externalization of membrane proteins
- allows ofr rapid excretion of granular contents
6
Q
Key platelet structures
Dense tubular system
A
- Remnants of MK endoplasmic reticular system
- Sequesters Ca important for platelete activation
7
Q
Alpha granules
- what do they contain
A
- conatin proteins involved in
- coagulation
- inflammation
- wound repair
8
Q
Dense delta granules
A
9
Q
where is vWF produced
where is it stored
A
- produced
- endothelial cells and MKs
- stored
- Veibel-Palade bodies
- granules in platelets
10
Q
what cleaves vWF
A
ADAMTS-13
11
Q
What serves as a anchor point from vWf to the platelet cytoskeleton?
A
- GP Ib/V/IX
12
Q
GP IV binding to collagen initaitos what?
A
signaling via
- phospholipase C and DAG/IP3
13
Q
what does endothelial cells make?
A
VwF and F8
14
Q
What is the first step in primary hemostasis?
A
- Vasoconstriction
15
Q
interiptoin of the endothelium exposes what?
A
- Tissue factor
- collagen (subendothelial collagen)
