12-04 L2 Lab aspects coagulation

Question 1

Lab testing mixing studies

what is seen with

• immediate acting
• Delayed acting

Answer 1

• immediate acting: lupus anticoagulants
• delayed acting: factor inhibitors

Question 2

What does thombin time do?

Answer 2

converts fibrinogne to fibrin (plasma + thrombin + Ca2+)

Question 3

What does reptilase time do?

what is it not prolonged by?

Answer 3

• converts fibrinogen to fibrin
• (plasma + repliatase):
• not prolonged by heprain

Question 4

Russel viper venom

Answer 4

• activates factor X directly
• (plasma + RVV + PL + Ca2+

Question 5

Echis carinatus time

Answer 5

• activates prothrombin directly
• (even if coumadinized)