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Hematology > 1.2 > Flashcards

1.2 Flashcards

1
Q

Hypersplenism is characterized by:

A. Polycythemia
B. Pancytosis
C. Leukopenia
D. Myelodysplasia

A

C. Leukopenia

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2
Q

Which of the following organs is responsible for the “pitting process” for RBCs?

A. Liver
B. Spleen
C. Kidney
D. Lymph nodes

A

B. Spleen

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3
Q

Spherocytes differ from normal red cells in all of the following except:

A. Decreased surface to volume
B. No central pallor
C. Decreased resistance to hypotonic saline
D. Increased deformability

A

D. Increased deformability

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4
Q

Which of the following is not associated with hereditary spherocytosis?

A. Increased osmotic fragility
B. An MCHC greater than 36%
C. Intravascular hemolysis
D. Extravascular hemolysis

A

C. Intravascular hemolysis

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5
Q

Which of the following disorders has an increase in osmotic fragility?

A. Iron deficiency anemia
B. Hereditary elliptocytosis
C. Hereditary stomatocytosis
D. Hereditary spherocytosis

A

D. Hereditary spherocytosis

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6
Q

The anemia seen in sickle cell disease is usually:

A. Microcytic, normochromic
B. Microcytic, hypochromic
C. Normocytic, normochromic
D. Normocytic, hypochromic

A

C. Normocytic, normochromic

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7
Q

Which is the major Hgb found in the RBCs of patients with sickle cell trait?

A. Hgb S
B. Hgb F
C. Hgb A2
D. Hgb A

A

D. Hgb A

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8
Q

Select the amino acid substitution that is responsible for sickle cell anemia.

A. Lysine is substituted for glutamic acid at the sixth position of the α-chain
B. Valine is substituted for glutamic acid at the sixth position of the β-chain
C. Valine is substituted for glutamic acid at the sixth position of the α-chain
D. Glutamine is substituted for glutamic acid at the sixth position of the β-chain

A

B. Valine is substituted for glutamic acid at the sixth position of the β-chain

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9
Q

All of the following are usually found in Hgb C disease except:

A. Hgb C crystals
B. Target cells
C. Lysine substituted for glutamic acid at the sixth position of the β-chain
D. Fast mobility of Hgb C at pH 8.6

A

D. Fast mobility of Hgb C at pH 8.6

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10
Q

Which of the following hemoglobins migrates to the same position as Hgb A2 at pH 8.6?

A. Hgb H
B. Hgb F
C. Hgb C
D. Hgb S

A

C. Hgb C

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11
Q

Which of the following electrophoretic results is consistent with a diagnosis of sickle cell trait?

A. Hgb A: 40% Hgb S: 35% Hgb F: 5%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
C. Hgb A: 0% Hgb A2: 5% Hgb F: 95%
D. Hgb A: 80% Hgb S: 10% Hgb A2: 10%

A

B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%

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12
Q

In which of the following conditions will autosplenectomy most likely occur?

A. Talassemia major
B. Hgb C disease
C. Hgb SC disease
D. Sickle cell disease

A

D. Sickle cell disease

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13
Q

Which of the following is most true of paroxysmal nocturnal hemoglobinuria (PNH)?

A. It is a rare acquired stem cell disorder that results in hemolysis
B. It is inherited as a sex-linked trait
C. It is inherited as an autosomal dominant trait
D. It is inherited as an autosomal recessive trait

A

A. It is a rare acquired stem cell disorder that results in hemolysis

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14
Q

Hemolytic uremic syndrome (HUS) is characterized by all of the following except:

A. Hemorrhage
B. Trombocytopenia
C. Hemoglobinuria
D. Reticulocytopenia

A

D. Reticulocytopenia

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15
Q

An autohemolysis test is positive in all the following conditions except:

A. Glucose-6-phosphate dehydrogenase (G6PD)
deficiency
B. Hereditary spherocytosis (HS)
C. Pyruvate kinase (PK) deficiency
D. Paroxysmal nocturnal hemoglobinuria (PNH)

A

D. Paroxysmal nocturnal hemoglobinuria (PNH)

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16
Q

Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?

A. Anti-I
B. Anti-i
C. Anti-M
D. Anti-P

A

D. Anti-P

17
Q

All of the following are associated with intravascular hemolysis except:

A. Methemoglobinemia
B. Hemoglobinuria
C. Hemoglobinemia
D. Decreased haptoglobin

A

A. Methemoglobinemia

18
Q

Autoimmune hemolytic anemia is best characterized by which of the following?

A. Increased levels of plasma C3
B. Spherocytic red cells
C. Decreased osmotic fragility
D. Decreased unconjugated bilirubin

A

B. Spherocytic red cells

19
Q

“Bite cells” are usually seen in patients with:

A. Rh null trait
B. Chronic granulomatous disease
C. G6PD deficiency
D. PK deficiency

A

C. G6PD deficiency

20
Q

The morphological classification of anemias is based on which of the following?

A. M:E (myeloid:erythroid) ratio
B. Prussian blue stain
C. RBC indices
D. Reticulocyte count

A

C. RBC indices

21
Q

Which of the following is a common finding in aplastic anemia?

A. A monoclonal disorder
B. Tumor infiltration
C. Peripheral blood pancytopenia
D. Defective DNA synthesis

A

C. Peripheral blood pancytopenia

22
Q

Congenital dyserythropoietic anemias (CDAs) are characterized by:

A. Bizarre multinucleated erythroblasts
B. Cytogenetic disorders
C. Megaloblastic erythropoiesis
D. An elevated M:E ratio

A

A. Bizarre multinucleated erythroblasts

23
Q

Microangiopathic hemolytic anemia is characterized by:

A. Target cells and Cabot rings
B. Toxic granulation and Döhle bodies
C. Pappenheimer bodies and basophilic stippling
D. Schistocytes and nucleated RBCs

A

D. Schistocytes and nucleated RBCs

24
Q

Which antibiotic(s) is (are) most often implicated in the development of aplastic anemia?

A. Sulfonamides
B. Penicillin
C. Tetracycline
D. Chloramphenicol

A

D. Chloramphenicol

25
Q

Sickle cell disorders are:

A. Hereditary, intracorpuscular RBC defects
B. Hereditary, extracorpuscular RBC defects
C. Acquired, intracorpuscular RBC defects
D. Acquired, extracorpuscular RBC defects

A

A. Hereditary, intracorpuscular RBC defects

26
Q

Which of the following conditions may produce spherocytes in a peripheral smear?

A. Pelger-Huët anomaly
B. Pernicious anemia
C. Autoimmune hemolytic anemia
D. Sideroblastic anemia

A

C. Autoimmune hemolytic anemia

27
Q

A patient’s peripheral smear reveals numerous NRBCs, marked variation of red cell morphology, and pronounced polychromasia. In addition to a
decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated?

A. Reduced platelets
B. Increased MCHC
C. Increased MCV
D. Decreased red-cell distribution width (RDW)

A

C. Increased MCV

28
Q

What red cell inclusion may be seen in the peripheral blood smear of a patient postsplenectomy?

A. Toxic granulation
B. Howell-Jolly bodies
C. Malarial parasites
D. Siderotic granules

A

B. Howell-Jolly bodies

29
Q

Reticulocytosis usually indicates:

A. Response to inflammation
B. Neoplastic process
C. Aplastic anemia
D. Red cell regeneration

A

D. Red cell regeneration

30
Q

Hereditary pyropoikilocytosis (HP) is a red cell membrane defect characterized by:

A. Increased pencil-shaped cells
B. Increased oval macrocytes
C. Misshapen budding fragmented cells
D. Bite cells

A

C. Misshapen budding fragmented cells

Hematology (7 decks)

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