1.2 Flashcards
Hypersplenism is characterized by:
A. Polycythemia
B. Pancytosis
C. Leukopenia
D. Myelodysplasia
C. Leukopenia
Which of the following organs is responsible for the “pitting process” for RBCs?
A. Liver
B. Spleen
C. Kidney
D. Lymph nodes
B. Spleen
Spherocytes differ from normal red cells in all of the following except:
A. Decreased surface to volume
B. No central pallor
C. Decreased resistance to hypotonic saline
D. Increased deformability
D. Increased deformability
Which of the following is not associated with hereditary spherocytosis?
A. Increased osmotic fragility
B. An MCHC greater than 36%
C. Intravascular hemolysis
D. Extravascular hemolysis
C. Intravascular hemolysis
Which of the following disorders has an increase in osmotic fragility?
A. Iron deficiency anemia
B. Hereditary elliptocytosis
C. Hereditary stomatocytosis
D. Hereditary spherocytosis
D. Hereditary spherocytosis
The anemia seen in sickle cell disease is usually:
A. Microcytic, normochromic
B. Microcytic, hypochromic
C. Normocytic, normochromic
D. Normocytic, hypochromic
C. Normocytic, normochromic
Which is the major Hgb found in the RBCs of patients with sickle cell trait?
A. Hgb S
B. Hgb F
C. Hgb A2
D. Hgb A
D. Hgb A
Select the amino acid substitution that is responsible for sickle cell anemia.
A. Lysine is substituted for glutamic acid at the sixth position of the α-chain
B. Valine is substituted for glutamic acid at the sixth position of the β-chain
C. Valine is substituted for glutamic acid at the sixth position of the α-chain
D. Glutamine is substituted for glutamic acid at the sixth position of the β-chain
B. Valine is substituted for glutamic acid at the sixth position of the β-chain
All of the following are usually found in Hgb C disease except:
A. Hgb C crystals
B. Target cells
C. Lysine substituted for glutamic acid at the sixth position of the β-chain
D. Fast mobility of Hgb C at pH 8.6
D. Fast mobility of Hgb C at pH 8.6
Which of the following hemoglobins migrates to the same position as Hgb A2 at pH 8.6?
A. Hgb H
B. Hgb F
C. Hgb C
D. Hgb S
C. Hgb C
Which of the following electrophoretic results is consistent with a diagnosis of sickle cell trait?
A. Hgb A: 40% Hgb S: 35% Hgb F: 5%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
C. Hgb A: 0% Hgb A2: 5% Hgb F: 95%
D. Hgb A: 80% Hgb S: 10% Hgb A2: 10%
B. Hgb A: 60% Hgb S: 40% Hgb A2: 2%
In which of the following conditions will autosplenectomy most likely occur?
A. Talassemia major
B. Hgb C disease
C. Hgb SC disease
D. Sickle cell disease
D. Sickle cell disease
Which of the following is most true of paroxysmal nocturnal hemoglobinuria (PNH)?
A. It is a rare acquired stem cell disorder that results in hemolysis
B. It is inherited as a sex-linked trait
C. It is inherited as an autosomal dominant trait
D. It is inherited as an autosomal recessive trait
A. It is a rare acquired stem cell disorder that results in hemolysis
Hemolytic uremic syndrome (HUS) is characterized by all of the following except:
A. Hemorrhage
B. Trombocytopenia
C. Hemoglobinuria
D. Reticulocytopenia
D. Reticulocytopenia
An autohemolysis test is positive in all the following conditions except:
A. Glucose-6-phosphate dehydrogenase (G6PD)
deficiency
B. Hereditary spherocytosis (HS)
C. Pyruvate kinase (PK) deficiency
D. Paroxysmal nocturnal hemoglobinuria (PNH)
D. Paroxysmal nocturnal hemoglobinuria (PNH)
Which antibody is associated with paroxysmal cold hemoglobinuria (PCH)?
A. Anti-I
B. Anti-i
C. Anti-M
D. Anti-P
D. Anti-P
All of the following are associated with intravascular hemolysis except:
A. Methemoglobinemia
B. Hemoglobinuria
C. Hemoglobinemia
D. Decreased haptoglobin
A. Methemoglobinemia
Autoimmune hemolytic anemia is best characterized by which of the following?
A. Increased levels of plasma C3
B. Spherocytic red cells
C. Decreased osmotic fragility
D. Decreased unconjugated bilirubin
B. Spherocytic red cells
“Bite cells” are usually seen in patients with:
A. Rh null trait
B. Chronic granulomatous disease
C. G6PD deficiency
D. PK deficiency
C. G6PD deficiency
The morphological classification of anemias is based on which of the following?
A. M:E (myeloid:erythroid) ratio
B. Prussian blue stain
C. RBC indices
D. Reticulocyte count
C. RBC indices
Which of the following is a common finding in aplastic anemia?
A. A monoclonal disorder
B. Tumor infiltration
C. Peripheral blood pancytopenia
D. Defective DNA synthesis
C. Peripheral blood pancytopenia
Congenital dyserythropoietic anemias (CDAs) are characterized by:
A. Bizarre multinucleated erythroblasts
B. Cytogenetic disorders
C. Megaloblastic erythropoiesis
D. An elevated M:E ratio
A. Bizarre multinucleated erythroblasts
Microangiopathic hemolytic anemia is characterized by:
A. Target cells and Cabot rings
B. Toxic granulation and Döhle bodies
C. Pappenheimer bodies and basophilic stippling
D. Schistocytes and nucleated RBCs
D. Schistocytes and nucleated RBCs
Which antibiotic(s) is (are) most often implicated in the development of aplastic anemia?
A. Sulfonamides
B. Penicillin
C. Tetracycline
D. Chloramphenicol
D. Chloramphenicol
Sickle cell disorders are:
A. Hereditary, intracorpuscular RBC defects
B. Hereditary, extracorpuscular RBC defects
C. Acquired, intracorpuscular RBC defects
D. Acquired, extracorpuscular RBC defects
A. Hereditary, intracorpuscular RBC defects
Which of the following conditions may produce spherocytes in a peripheral smear?
A. Pelger-Huët anomaly
B. Pernicious anemia
C. Autoimmune hemolytic anemia
D. Sideroblastic anemia
C. Autoimmune hemolytic anemia
A patient’s peripheral smear reveals numerous NRBCs, marked variation of red cell morphology, and pronounced polychromasia. In addition to a
decreased Hgb and decreased Hct values, what other CBC parameters may be anticipated?
A. Reduced platelets
B. Increased MCHC
C. Increased MCV
D. Decreased red-cell distribution width (RDW)
C. Increased MCV
What red cell inclusion may be seen in the peripheral blood smear of a patient postsplenectomy?
A. Toxic granulation
B. Howell-Jolly bodies
C. Malarial parasites
D. Siderotic granules
B. Howell-Jolly bodies
Reticulocytosis usually indicates:
A. Response to inflammation
B. Neoplastic process
C. Aplastic anemia
D. Red cell regeneration
D. Red cell regeneration
Hereditary pyropoikilocytosis (HP) is a red cell membrane defect characterized by:
A. Increased pencil-shaped cells
B. Increased oval macrocytes
C. Misshapen budding fragmented cells
D. Bite cells
C. Misshapen budding fragmented cells
