118 Microcirculation Flashcards
Circulation methods for:
Gas Exchange
Water Soluble Solvents
Macromolecular Transport
Gas: through tissue, diffuses down gradient
Water solvents: tight junctions
Macro: through differeent capillaries (fenestrations, gaps, transcytosis)

van’t Hoff equation
- Reflection Coefficient:
- 0 : Perfectly permeable
- 1 : Perfectly impermeable
- Good approximation:
- Only proteins have a reflection coefficient of 1
Starling equation: for capillary flow

How does net filtration pressure change along the capillary

Lymphatic circulation

parallel circulation

- Microvalves
- 2-4 L flow / day
- Drains excess fluid from interstitium (net loss of fluid from capillary to interstitum)
Mechanisms for Control of Regional Blood Flow
Systemic:
- oNeural Mechanisms
- oHormonal Mechanisms
Local:
- oMyogenic Mechanisms
- oMetabolic Mechanisms
- oEndothelial Mechanisms
Sympathetic Regulation of Blood Flow

Histimine Regulation of Blood Flow

Myogenic Regulation of Blood Flow

Metabolic Regulation of Blood Flow

Epithelial Regulation: Nitric Oxide
Blood Flow

Epithelial Regulation: Endothelin
Blood Flow

Active vs Reactive Hyperemia

Coronary Circulation
Cerebral Circulation

Pulmonary circulation

Skeletal Muscle Circulation

Skeletal Muscle: Muscle Pump
