11-Wound Care Flashcards
What are the stages of wound healing?
inflammatory phase
proliferative (repair) phase
remodeling (maturation) phase
in what stage of healing do chronic wounds stop progressing?
proliferative (repair) phase
what occurs during inflammatory phase? time scale/
(days 1-4)
initial vasoconstriction followed by vasodilation
neutrophils and macrophages are recruited
what occurs during proliferative (repair) phase? time scale?
(days 3-21)
collagen synthesis provides tensile strength of wound
at 14 days, tensile strength of wound equals that of suture
what is the time scale for remodeling (maturation) phase?
days 21 up to one year
What is Santyl?
collagenase- enzymatic debrider that digests collagen in necrotic tissue
what is Regranex?
PDGF-1 (platelet derived growth factor)
What is a normal value for serum albumin?
3.4-5.0 g/dL
what is low serum album (
decreased wound healing edema impaired cellular immunity decreased collagen syntehsis decreased fibroblast proliferation
what minimum ABI is necessary for wound healing?
non-diabetic: 0.35
diabetic: 0.45
Using TcO2, what min. pressure is necessary for wound healing?
non-diabetic: 30 mmgHg
diabetic: 40 mmHg
how does negative pressure wound therapy (NPWT) (e.g. wound VAC) assist wound closure?
NPWT applies mechanical shear stress to the wound site. This is believed to promote granulation by decreasing bacterial bioburden, reducing edema, and inducing capillary budding.
how does hyperbaric oxygen therapy assist wound closure?
increases partial pressure of O2 in arterial circulation, which increases diffusion of O2 at the wound site. this is believed to increase growth factors promoting angiogenesis and collagen synthesis.
What is Integra?
bilayer graft composed of bovine tendon colalgen with chondroitin-6-sulfate and a silicone layer to control moisture loss
what is Oasis?
extracellular graft matrix derived from porcine, small intenstinal submucosa
