11 Muscle contraction Flashcards
EXAM QUESTION
What is the role of phosphocreatine (PC) in providing energy during muscle
contraction? (2)
- (Phosphocreatine) provides
phosphate/phosphorylates; - To make ATP;
EXAM QUESTION
There is a lot of variation in the time taken for PC to be re-formed in people of a very
similar age.
Suggest one reason for this variation. (1)
One suitable suggestion; eg 1. Genetic differences; 2. Level of fitness/amount of regular exercise done/mass of muscle; 3. Sex; 4. Ethnicity 5. Metabolic rate; 6. Number of fast/slow muscle fibres
EXAM QUESTION
Use your knowledge of fast muscle fibres to explain the effect of age on them. (4)
- (From graph, phosphocreatine) takes longer to
remake as people get older; - Fast muscle fibres used for
rapid/brief/powerful/strong contractions; - Phosphocreatine used up rapidly during
contraction/to make ATP; - (As people get older) slower metabolic
rate/slower ATP production/slower respiration; - Anaerobic respiration involved;
- ATP used to reform phosphocreatine;
- Lots of phosphocreatine in fast fibres;
EXAM QUESTION
You could use an optical microscope and a slide of stained muscle tissue to find the
diameter of one of the muscle fibres. Explain how. (2)
Measure with graticule/eyepiece scale;
Calibrate against something of known size:
EXAM QUESTION
A student found the mean diameter for the slow muscle fibres in a section. Give two
precautions that she should have taken when sampling the fibres. Give a reason for
each precaution. (2)
Equivalent measurements taken;
At random to avoid bias/avoid choice of particular fibres;
Large number to be representative/minimise effect of
extremes/of anomalies;
EXAM QUESTION
When the sarcomeres contract, what happens to the length of
the I-band?
the A-band?
Decreases;
Nothing / stays the same length /
does not change;
EXAM QUESTION
The length of each sarcomere in the diagram is 2.2 μm. Use this information to calculate the magnification of the diagram. Show your working.
Image = 67mm
- M = I/O
- M=67mm/2.2um
- 67 x 1000 = 67,000um
- 67,000/2.2 = 30454
People who have McArdle’s disease produce less ATP than healthy people. As a
result, they are not able to maintain strong muscle contraction during exercise. Use
your knowledge of the sliding filament theory to suggest why. (3)
(Idea ATP is needed for:) 1. Attachment/cross bridges between actin and myosin; 2. ‘Power stroke’ / movement of myosin heads / pulling of actin; 3. Detachment of myosin heads; 4. Myosin heads move back/to original position / ‘recovery stroke’;
Describe the part played by each of the following in myofibril contraction.
Tropomyosin (2)
Myosin (2)
- Moves out of the way when calcium
ions bind; - Allowing myosin to bind (to
actin)/crossbridge formation;
1. Head (of myosin) binds to actin and moves/pulls/slides actin past; 2. (Myosin) detaches from actin and re-sets/moves further along (actin) 3. This uses ATP;
Suggest and explain one advantage of:
the high glycogen content of fast muscle fibres (anaerobic)(2)
many capillaries supplying slow muscle fibres (aerobic)(2)
(Glycogen broken down) gives (lots of) glucose for glycolysis/anaerobic respiration; 2. Glycolysis/anaerobic respiration not very efficient/only yields 2 ATP per glucose;
1. (Many capillaries) give high concentration/lots of oxygen/ shorter diffusion pathway for oxygen/large surface area for oxygen exchange/diffusion; 2. Good glucose supply with little glycogen present; 3. Allows high rate of/more aerobic respiration OR prevents build-up of lactic acid/(muscle) fatigue;
EXAM QUESTION
Cannabinoid receptors are found in the pre-synaptic membrane of neuromuscular
junctions. When a cannabinoid binds to its receptor, it closes calcium ion channels.
Suggest how cannabinoids could prevent muscle contraction (4)
1. Prevents influx of calcium ions (into pre-synaptic membrane); 2. (Synaptic) vesicles don’t fuse with membrane / vesicles don’t release neurotransmitter; 3. Neurotransmitter does not diffuse across synapse/does not bind to receptors (on post-synaptic membrane); 4. No action potential/depolarisation (of post-synaptic membrane)/ sodium (ion) channels do not open / prevents influx of sodium ions;
EXAM QUESTION
Multiple sclerosis (MS) is a disease that involves damage to the myelin sheaths of neurones. Movement in MS sufferers may be jerky or slow.
Damage to the myelin sheaths of neurones can lead to problems controlling the
contraction of muscles.
Suggest one reason why. (2)
One suitable suggestion; explained; Eg 1. Action potentials travel more slowly/don’t travel; 2. So delay in muscle contraction/muscles don’t contract/muscles contract slow(er); OR 3. Action potentials/depolarisation ‘leaks’ to adjacent neurones; 4. So wrong muscle (fibres) contract;
Myofibrils:
How are they arranged?
What do they share? (4)
Made up of? (4)
To provide maximum force
Nuclei and cytoplasm/sarcoplasm (high conc. mitochondria and ER)
2 protein filaments
- Actin (thin)
- Myosin (thick)
Myofibrils made up of alternating bands:
Alternating bands:
I-band? (3)
A-band (2)
Light-coloured because no overlap
Z-line - centre of each I-band
Sarcomere = distance between adjacent Z-lines
Dark-coloured because overlap
H-zone - light-coloured region at centre of each A-band
Give 4 features of slow twitch fibres
Adaptations suited to role? (2)
Contract slowly
Less powerful
Longer period (endurance)
Aerobic
Many capillaries
Many mitochondria