11. ANS Pharmacology DSA Flashcards
What mechanism of intracellular activation is utilized by Gq utilizing muscarine receptors?
What about Gi/o utilizing receptors?
Gq = Phospholipase C
Gi/o = Adenylyl cyclase inhibition
Which three muscarine receptors are associated with Gq structures?
Which adrenergic receptor uses Gq?
M1, M3, M5 use Gq
Alpha 1 adrenergic receptors use Gq
Which adrenergic receptor is activated much more significantly by epinephrine than norepinephrine?
What does that receptor do?
Beta 2 receptors are activated much more strongly by epinephrine than norepinephrine
They relax the smooth muscles areound blood vessels (vasodilation), as well as the smooth muscle around the lungs
What is the intracellular mechanism activated by beta adrenergic receptors?
Increase of adenylyl cyclase
What is the general function of alpha 1 receptors?
Alpha 1 receptors cause contraction of all smooth muscle
What is the general function of beta 2 receptors?
Relaxation of all smooth muscle
(Tracheal, bronchial, uterine)
What is the general function of muscarinic receptors?
Contraction of all smooth muscle
What is the effect of beta 1 receptors on the heart?
Increae heart rate, contractility, and conduction velocity generally.
What is the effect of M2 receptors on the heart?
Decrease in heart rate, contractility, conduction velocity.
Mostly acts at the sinuatrial node.
What is the function of beta 2 receptors on the tracheal and bronchial smoth muscle?
Relax the smooth muscle
What is the effect of muscarinic receptors on the smooth muscle of the trachea and bronchi?
Contraction
What three receptors act on the bronchial glands, and what are their actions?
Alpha 1 = decreases secretion
Beta 2 = increases secretion
M3 / M2 = increases secretion
What is the effect of myocardial inhibition of the Na/K pump?
Increased intracellular Na,
Decreased effect of the sodium / calcium exchanger
Increased calcium available for contractile cells (increased contractility)
Lengthened phase 4 (decreased heart rate)
